PMID: 3384368Jun 1, 1988Paper

Pancreaticoduodenal secretions and the genesis of gastric stump carcinoma in the rat

Gut
R C MasonI McColl

Abstract

This study was designed to investigate the role of duodenogastric reflux in the genesis of gastric stump carcinoma in the rat. Carcinoma was not detected in any of the 11 control animals and in only one animal with a Roux diversion. In contrast seven of 12 animals with duodenogastric reflux developed carcinoma (p less than 0.01 and p less than 0.05 respectively). In order to determine which fraction of the reflux was implicated in the malignant process, animals with reflux of bile alone or pancreaticoduodenal secretions alone were studied. No carcinomas were found in 11 animals with bile reflux alone, but carcinoma was detected in 10 of 14 animals with reflux of pancreaticoduodenal secretions (p less than 0.01). The findings confirm that duodenogastric reflux is an important factor in the malignant process, and imply that the pancreaticoduodenal component, not bile is responsible.

References

Jan 1, 1979·Journal of Cancer Research and Clinical Oncology·E KunzeC Seefeldt
Nov 1, 1979·World Journal of Surgery·J C Nicholls
Oct 1, 1986·The British Journal of Surgery·R C Mason
Jun 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Bruusgaard
Aug 1, 1980·American Journal of Surgery·L DomellöfJ H Weisburger

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Citations

Nov 7, 1998·The Veterinary Journal·M Sullivan, D A Yool
Dec 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R EhrnströmY M Ehrnström
Nov 11, 2010·Annals of Surgical Oncology·James J MezhirDaniel G Coit
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·Y SetoY Morioka
Oct 1, 1990·Scandinavian Journal of Gastroenterology·R Mason, I Filipe
Jan 1, 1997·The British Journal of Surgery·R E MarshallW J Owen
Oct 30, 2015·Journal of Surgical Oncology·Thuy B TranGeorge A Poultsides
Oct 31, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C SinningM Wolff
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·Roy A EhrnströmTommy Andersson
Jan 1, 1994·The British Journal of Surgery·A D HoughtonR C Mason
Dec 17, 2014·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M Victorzon
Dec 24, 2005·Scandinavian Journal of Gastroenterology·Roy A EhrnströmClas G Lindström
Feb 6, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tamer M Said Salama, Mohamed Ibrahim Hassan
Sep 10, 2019·Journal of Surgical Oncology·Keita SonodaJeannelyn S Estrella
Aug 15, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hirokazu YamaguchiJeffrey R Lee
Sep 22, 2020·Surgery Open Science·Michael Johannes PflügerRichard Andrew Burkhart

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