Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma

The Cochrane Database of Systematic Reviews
Markus K DienerHanns-Peter Knaebel

Abstract

Pancreatic cancer is the fourth leading cause of cancer death for men and the fifth for women. The standard treatment for resectable tumours is either a classic Whipple operation or a pylorus-preserving pancreaticoduodenectomy but it is still unclear which of the two procedures is more favourable in terms of survival, mortality, complications, perioperative factors and quality of life. Several publications pointed out both advantages and disadvantages of both techniques and the current basis of evidence remains unclear. The objective of this systematic review is to compare the effectiveness of each technique. A search was conducted to identify all published and unpublished randomised controlled trials. Trials were identified by searching the following electronic databases - The Cochrane Library, MEDLINE, EMBASE and Current Contents. Reference lists from trials selected by electronic searching were hand-searched to identify further relevant trials. Randomised controlled trials (RCTs) comparing the classical Whipple (CW) with the pylorus-preserving pancreaticoduodenectomy (PPW) were considered eligible if patients with periampullary or pancreatic carcinoma were included. Two authors independently extracted data for included studi...Continue Reading

Citations

May 7, 2009·Langenbeck's Archives of Surgery·Traian DumitrascuIrinel Popescu
Jul 14, 2012·World Journal of Gastroenterology : WJG·Mehdi OuaïssiBernard Sastre
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May 26, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·I GastingerH Dralle
Sep 20, 2011·Journal of Visceral Surgery·C NeuzilletP Hammel

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