Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer

World Journal of Surgical Oncology
Rebecca ZhuSajid A Khan

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut. We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature. Locally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.

References

Feb 13, 2004·International Journal of Cancer. Journal International Du Cancer·Wouter H de Vos tot Nederveen CappelHans F A Vasen
May 13, 2008·Diseases of the Colon and Rectum·Y Nancy YouJeffrey Harrington
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Dec 7, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Madhuri HegdeUNKNOWN Working Group of the American College of Medical Genetics and Genomics (ACMG) Laboratory Quality Assurance Committee
Apr 23, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sara J TempleAlice C Wei
Feb 11, 2015·Diseases of the Colon and Rectum·Tushar SamdaniGarrett M Nash

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Citations

Mar 1, 2021·World Journal of Emergency Surgery : WJES·Joe-Bin ChenFang-Ku P'eng

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Methods Mentioned

BETA
surgical resection
biopsies

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