PMID: 2119213May 1, 1990Paper

Pancreatitis in children on chronic dialysis treated with valproic acid

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D M FordG M Lum

Abstract

Four children treated with maintenance dialysis, three peritoneal and one hemodialysis, developed pancreatitis while receiving valproic acid (VPA) for chronic seizure disorders. Two patients recovered, eventually resuming VPA therapy after successful cadaveric renal transplantation. Two children died after complications of pancreatitis. No episodes of pancreatitis occurred in the other 74 children in this maintenance dialysis population; none of whom received VPA. Although pancreatitis is a known complication of VPA treatment or end-stage renal disease (ESRD), this is the first reported series specifically relating pancreatitis to VPA administration in children treated with maintenance dialysis. The literature related to the association of pancreatitis with VPA administration and ESRD therapy is briefly reviewed and the clinical implications are discussed.

References

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Citations

Feb 27, 2007·Journal of Gastroenterology·Thorsten GerstnerStephan König
Apr 18, 2003·Pediatric Neurology·Nancy L Grauso-EbyGary N McAbee
Mar 28, 2007·Epilepsia·Gaetano ZaccaraEmilio Perucca
Jan 5, 2002·Pharmacotherapy·S A ChapmanB D Patterson
Mar 31, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nison BadalovScott Tenner
Nov 6, 2004·Journal of Child Neurology·D Barry SinclairRene Breault
Mar 1, 2002·Expert Review of Neurotherapeutics·Andres M Kanner, Antoaneta Balabanov
Oct 27, 2011·European Journal of Gastroenterology & Hepatology·Farhabanu MangaMichael Guest
Feb 1, 1996·Alimentary Pharmacology & Therapeutics·K E McArthur
Sep 2, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anil R Balani, James H Grendell
Aug 25, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Enrico VidalUNKNOWN Italian Registry of Pediatric Chronic Dialysis
Apr 11, 2018·Clinical Medicine Insights. Case Reports·Roberta AliottaFrancesco Rapisarda

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