PMID: 6109989Feb 14, 1981Paper

Pancuronium during mechanical ventilation speeds recovery of lungs of infants with hyaline membrane disease

Lancet
M J PollitzerR M Thomas

Abstract

Spontaneous breathing during mechanical ventilation in newborn infants may damage the lung. To find out whether the prevalence of lesions which might be due to trauma was reduced by muscle relaxation, fifty infants who required mechanical ventilation of hyaline membrane disease were randomly assigned to treated and control groups. The treated infants were kept muscle relaxed with pancuronium bromide until they needed a FiO2 of 0.40 or less during ventilation. The mean birthweight, gestational age, age at entry to the trial, duration of intubation and ventilation, FiO2 during the acute phase of the illness, and ventilator pressures were closely comparable in the two groups. Two of twenty-six treated infants and one of twenty-four controls died. Four treated and five control infants acquired pneumothoraces and/or interstitial emphysema. The length of time that the treated infants required added oxygen was significantly less than in the control infants. All treated infants were breathing room air spontaneously by one month of age whereas seven control infants were still dependent on added oxygen, needing an average FiO2 of 0.35 to achieve a mean PaO2 of 6.5 kPa (49 mm Hg). These seven infants required added oxygen until they were ...Continue Reading

References

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Citations

Mar 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K T FitzpatrickR K Mirakhur
Oct 10, 1985·The New England Journal of Medicine·E O ReynoldsM D Whitehead
Jun 12, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M KapasiR M Kacmarek
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Nov 1, 1995·Clinical Pediatrics·O P Mathew
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Feb 4, 2009·Current Opinion in Critical Care·Jean-Marie ForelLaurent Papazian
Sep 4, 2012·Current Opinion in Critical Care·Sami HraiechLaurent Papazian
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Nov 1, 1986·Journal of Clinical Pharmacology·J MartynN G Goudsouzian
Nov 18, 1997·Acta Paediatrica Japonica; Overseas Edition·J Y ChenJ H Chen

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