Pancytopenia associated with clonazepam.

Journal of Hematology & Oncology
Marnelli A Bautista-QuachChung-Tsen Hsueh

Abstract

We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow (10-20% total cellularity). Clonazepam was discontinued, with gradual improvement of thrombocytopenia, and neutropenia in 1-2 weeks. To our knowledge, this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia.

References

Oct 1, 1976·Archives of Neurology·S Livingston, L L Pauli
Nov 22, 1975·British Medical Journal·R M Veall, H C Hogarth
May 7, 1988·British Medical Journal·S el-Sayed, R P Symonds
Apr 2, 1982·JAMA : the Journal of the American Medical Association·S MandelM Rudmick
Apr 3, 2002·Annals of Internal Medicine·Neal S Young
Nov 30, 2004·Clinical Neurology and Neurosurgery·R Brouns, P P De Deyn

❮ Previous
Next ❯

Citations

Mar 13, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A VerrottiG Coppola
Mar 14, 2013·Revista española de geriatría y gerontología·Omar Alejandro Rangel SelveraIsidoro Ruiperez Cantera
Feb 8, 2021·BMC Psychiatry·Natalie MartosFrederick C Nucifora

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

JAMA : the Journal of the American Medical Association
S L GreenE D Huttenbach
Journal of Laboratory Physicians
B N Gayathri, Kadam Satyanarayan Rao
© 2021 Meta ULC. All rights reserved