Pandemic 2009 influenza A (H1N1) virus among Japanese healthcare workers: seroprevalence and risk factors

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Yoko NukuiKyoji Moriya


To evaluate the seroprevalence and risk factors for 2009 influenza A (H1N1) virus infection among healthcare personnel. Observational cross-sectional study. Healthcare workers (HCWs) in an acute care hospital. Between September 14 and October 4, 2009, before 2009 H1N1 vaccination, we collected serological samples from 461 healthy HCWs. Hemagglutination-inhibition antibody assays were conducted. To evaluate the risk factors of seropositivity for 2009 H1N1 virus, gender, age, profession, work department, usage of personal protective equipment, and seasonal influenza vaccination status data were gathered via questionnaires. Our survey showed that doctors and nurses were at highest risk of seropositivity for the 2009 H1N1 virus (odds ratio [OR], 5.25 [95% confidence interval {CI}, 1.21-22.7]). An increased risk of seropositivity was observed among pediatric, emergency room, and internal medicine staff (adjusted OR, 1.98 [95% CI, 1.07-3.65]). Risk was also higher among HCWs who had high titers of antibodies against the seasonal H1N1 virus (adjusted OR, 1.59 [95% CI, 1.02-2.48]). Seropositivity for the 2009 H1N1 virus was associated with occupational risk factors among HCWs.


Jan 31, 2008·American Journal of Epidemiology·F CarratAlain-Jacques Valleron
May 9, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·H MelzlH H Niller
Oct 1, 2009·Emerging Infectious Diseases·Helen BernardManfred Wildner
Nov 17, 2009·Pediatric Emergency Care·Rini Jain, Ran D Goldman
Apr 10, 2010·The Journal of Infectious Diseases·L L H LauGabriel M Leung
Aug 25, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M LemaitreF Carrat
Sep 15, 2010·Influenza and Other Respiratory Viruses·Koji WadaAkihiko Kawana

Related Concepts

Antibodies, Viral
Prevalence Studies
Disease Outbreaks
Personnel, Hospital
Confidence Intervals
Odds Ratio
Occupational Exposure

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