PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data

Genome Medicine
Elena Piñeiro-YáñezFátima Al-Shahrour

Abstract

Large-sequencing cancer genome projects have shown that tumors have thousands of molecular alterations and their frequency is highly heterogeneous. In such scenarios, physicians and oncologists routinely face lists of cancer genomic alterations where only a minority of them are relevant biomarkers to drive clinical decision-making. For this reason, the medical community agrees on the urgent need of methodologies to establish the relevance of tumor alterations, assisting in genomic profile interpretation, and, more importantly, to prioritize those that could be clinically actionable for cancer therapy. We present PanDrugs, a new computational methodology to guide the selection of personalized treatments in cancer patients using the variant lists provided by genome-wide sequencing analyses. PanDrugs offers the largest database of drug-target associations available from well-known targeted therapies to preclinical drugs. Scoring data-driven gene cancer relevance and drug feasibility PanDrugs interprets genomic alterations and provides a prioritized evidence-based list of anticancer therapies. Our tool represents the first drug prescription strategy applying a rational based on pathway context, multi-gene markers impact and informa...Continue Reading

References

Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
May 15, 2007·Oncogene·A S DhillonW Kolch
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anthony C FaberJeffrey A Engelman
Feb 5, 2010·Cancer Cell·Alexa B TurkePasi A Jänne
May 3, 2011·Trends in Biochemical Sciences·Michelle C MendozaJohn Blenis
Aug 28, 2012·Science·Gopa IyerDavid B Solit
Oct 13, 2012·Nature Reviews. Drug Discovery·Gideon BollagPeter Hirth
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Levi A GarrawayKarla V Ballman
Oct 3, 2013·Scientific Reports·David TamboreroNuria Lopez-Bigas
Oct 15, 2013·Nature Methods·Malachi GriffithRichard K Wilson
Nov 30, 2013·Nature Reviews. Drug Discovery·Paul Workman, Bissan Al-Lazikani
Mar 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena GarraldaManuel Hidalgo
Oct 26, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AndreC Swanton
Feb 7, 2015·Cancer Discovery·Rodrigo DienstmannJustin Guinney
Nov 22, 2015·Nucleic Acids Research·Bjoern-Oliver GohlkeRobert Preissner
Mar 19, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Justin F GainorJeffrey A Engelman
May 4, 2016·Nucleic Acids Research·Francisco SalavertJoaquín Dopazo
Jun 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra Ortiz-CuaranMartin L Sos
Jun 21, 2016·Scientific Reports·Andreas SchlickerLodewyk F A Wessels
Jul 12, 2016·Cell·Francesco IorioMathew J Garnett
Dec 3, 2016·Nucleic Acids Research·Simon A ForbesPeter J Campbell
Dec 16, 2016·Nature Reviews. Cancer·Andrea Califano, Mariano J Alvarez
Feb 1, 2017·Nature Genetics
Feb 12, 2017·Cell·David M HymanJosé Baselga
Mar 4, 2017·Nature Reviews. Cancer·Günter SchneiderDieter Saur
Apr 21, 2017·PLoS Computational Biology·Thomas A PetersonMaricel G Kann
Jul 29, 2017·Cell·Aviad TsherniakWilliam C Hahn

❮ Previous
Next ❯

Citations

Jun 8, 2019·Bioinformatics·Javier Perales-PatónFátima Al-Shahrour
Nov 22, 2019·Briefings in Bioinformatics·Hongcheng YaoMulin Jun Li
Oct 3, 2018·BioMed Research International·Rosa Doñate PuertasPhilippe Chevalier
Sep 12, 2020·BMC Genomics·Guidantonio Malagoli Tagliazucchi, Cristian Taccioli
Oct 28, 2019·BMC Cancer·Pablo Fernández-NavarroJosé Fernández-Piqueras
Jul 9, 2020·Nature Communications·Mary J GoldmanMiguel Vazquez
May 10, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianzhen LinHaitao Zhao
Jul 17, 2020·Computational and Structural Biotechnology Journal·Alexandria Lau, Hon-Cheong So
Jan 14, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Rosa Doñate PuertasPhilippe Chevalier
Feb 7, 2021·Reproductive Biology·Sriharikrishnaa SShama Prasada Kabekkodu
Feb 26, 2021·Nature Communications·Biyu ZhangQi Liu
May 1, 2021·Frontiers in Medicine·Vitali SintchenkoBen Marais
May 11, 2021·Briefings in Bioinformatics·Florian BorchertMatthieu-P Schapranow
Jul 25, 2021·Scientific Reports·Hamidreza Aboulkheyr EsMehdi Totonchi
Jul 25, 2021·Cancers·Dimitra MavridouMichalis Aivaliotis

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
exome sequencing

Clinical Trials Mentioned

NCT02520778
NCT02694224

Software Mentioned

TumorPortal
OncoKB
PubChem
Cancer Genome Interpreter ( CGI )
GDSC
OncoScape
COSMIC
PanDrugs
DGIdb
cBioPortal

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.