Panel of prototypical raltegravir-resistant infectious molecular clones in a novel integrase-deleted cloning vector.

Antimicrobial Agents and Chemotherapy
Elizabeth C ReumanRobert W Shafer

Abstract

We created an HIV-1 cloning vector, pNL4.3DeltaIN, to generate recombinant infectious molecular clones for analysis of patient-derived HIV-1 integrase coding regions. Using this vector, we constructed a panel of clinically derived viruses with the canonical patterns of raltegravir resistance mutations and submitted the panel to the NIH AIDS Research and Reference Reagent Program. Investigational integrase inhibitors with activity against these clones are likely to retain activity against the most clinically relevant raltegravir-resistant variants.

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Citations

Apr 5, 2011·The Journal of Infectious Diseases·Jose-Luis BlancoRobert W Shafer
Dec 25, 2012·BMC Infectious Diseases·Miłosz ParczewskiAnna Boroń-Kaczmarska
Sep 18, 2012·Current Opinion in Virology·Isabelle MaletAnne-Geneviève Marcelin
Dec 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon L KarmonMartin Markowitz
Jan 8, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S RusconiUNKNOWN Antiretroviral Resistance Cohort Analysis Collaborative Group
Jun 11, 2016·Journal of Medicinal Chemistry·Bulan WuZhengqiang Wang
Oct 26, 2016·Scientific Reports·Sui-Yuan ChangShan-Chwen Chang
Jul 5, 2016·Molecular Biotechnology·Chakradhar KokkulaJohan Lennerstrand
Aug 19, 2018·Retrovirology·Maureen OliveiraUNKNOWN Montreal Primary HIV (PHI) Cohort Study Group
Jan 19, 2021·Bioorganic & Medicinal Chemistry·Francesca CurreliAsim K Debnath

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