Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis

The Journal of Molecular Diagnostics : JMD
Vida KocbekTea Lanišnik Rižner

Abstract

Endometriosis is a gynecologic disease that is characterized by nonspecific symptoms and invasive diagnostics. To date, there is no adequate noninvasive method for the diagnosis of endometriosis. Although more than 100 potential biomarkers have been investigated in blood and/or peritoneal fluid, none of these has proven useful in clinical practice. The aim to find a suitable panel of biomarkers that would allow noninvasive diagnosis thus remains of interest. We evaluated the concentrations of 16 cytokines and other secretory proteins in serum and peritoneal fluid of 58 women with ovarian endometriosis (cases) and 40 healthy women undergoing sterilization or patients with benign ovarian cysts (controls) using multiplexed double fluorescence-based immunometric assay platform and enzyme-linked immunosorbent assay. Significantly higher concentrations of glycodelin-A were shown in serum, and significantly higher levels of glycodelin-A, IL-6, and IL-8, and lower levels of leptin were measured in the peritoneal fluid of cases versus controls. In serum, the best performance was shown by models that included the ratio of leptin/glycodelin-A and the ratio of ficolin 2/glycodelin-A, whereas in the peritoneal fluid the best models included...Continue Reading

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Citations

Feb 2, 2016·Systems Biology in Reproductive Medicine·Vladislav S BaranovMaria I Yarmolinskaya
Feb 28, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Katja VoukTea Lanišnik Rižner
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Jan 28, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zongquan ZhaoMin Huang

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