Paneth cell-rich flat adenoma of the rectum: report of a case

Japanese Journal of Cancer Research : Gann
C A RubioL Bry

Abstract

A patient having familiar adenomatosis polyposis and an ileo-rectal anastomosis developed a flat mucosal lesion in the rectum. A punch biopsy revealed a villous adenoma with high-grade dysplasia. The subsequent surgical specimen indicated that the flat villous adenoma was rich in Paneth cells. Special stains included lysozyme muramidase (to visualize Paneth cells), MIB1 proliferation monoclonal antibody and single and multilabel immunohistochemistry for Paneth cells. Other methods included transmission electron microscopy and quantification with an image quantifier (Program Optilab 2.1) of lysozyme-stained Paneth cells. The subjective evaluation of hematoxylin-eosin-stained preparations demonstrated that the Paneth cells were mainly located in the lower half of the villi. Sections labeled with a specific stain (lysozyme muramidase) revealed more Paneth cells in the villi and electron microscopy showed even more in lysozyme-negative areas. Obviously some migrating dysplastic Paneth cells had retained their characteristic granules on their way towards the tip of the villi. Quantitative studies indicated that the lysozyme muramidase-positive material accounted for 41% of the adenomatous tissue. MIB1 revealed intense cell prolifera...Continue Reading

References

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Citations

Sep 23, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T J NevalainenT Ekfors
May 3, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Youhei MantaniHiroshi Kitagawa
Dec 31, 1998·Gastroenterology·M Bjerknes, H Cheng
Jul 1, 2014·Gastrointestinal Endoscopy Clinics of North America·Carlos A Rubio, Premysl Slezak
Aug 1, 1996·Japanese Journal of Cancer Research : Gann·C A RubioT Muto
May 16, 2008·Nature Reviews. Cancer·Adam Humphries, Nicholas A Wright
Dec 14, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nikolaus GasslerFrank Autschbach
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Matthew Bjerknes, Hazel Cheng

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