Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

Cell Reports
Mark SchmittRiccardo Fodde

Abstract

IBD syndromes such as Crohn's disease and ulcerative colitis result from the inflammation of specific intestinal segments. Although many studies have reported on the regenerative response of intestinal progenitor and stem cells to tissue injury, very little is known about the response of differentiated lineages to inflammatory cues. Here, we show that acute inflammation of the mouse small intestine is followed by a dramatic loss of Lgr5+ stem cells. Instead, Paneth cells re-enter the cell cycle, lose their secretory expression signature, and acquire stem-like properties, thus contributing to the tissue regenerative response to inflammation. Stem cell factor secretion upon inflammation triggers signaling through the c-Kit receptor and a cascade of downstream events culminating in GSK3β inhibition and Wnt activation in Paneth cells. Hence, the plasticity of the intestinal epithelium in response to inflammation goes well beyond stem and progenitor cells and extends to the fully differentiated and post-mitotic Paneth cells.

Citations

Aug 31, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Diya DasJohn Ngai
Apr 1, 2019·Molecular Cancer·Maartje van der Heijden, Louis Vermeulen
Apr 10, 2020·EMBO Reports·Laura MarruecosLluís Espinosa
Sep 23, 2020·Nature Reviews. Molecular Cell Biology·Joep Beumer, Hans Clevers
Feb 2, 2019·F1000Research·Deqing HuLinheng Li
Jul 25, 2019·World Journal of Gastroenterology : WJG·Simon Buczacki
Aug 30, 2019·Stem Cells Translational Medicine·Sara Duhachek-MuggyFrank Pajonk
Feb 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Soham KarmakarLinheng Li
Aug 14, 2020·Stem Cell Research & Therapy·Xianglin MeiMeiying Li
Jul 1, 2020·Tissue Engineering and Regenerative Medicine·Harikrishna Reddy RallabandiBo Ram Lee
Jan 14, 2020·Journal of Immunology Research·Hui FanYin Lu
Nov 17, 2020·International Journal of Cancer. Journal International Du Cancer·Rhiannon French, Siim Pauklin
Jan 6, 2021·International Journal of Molecular Sciences·Ken KurokawaKazuhiko Koike
Jul 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Marimar de la Cruz BonillaHelen Piwnica-Worms
Jun 9, 2020·Mechanisms of Ageing and Development·Dovydas SirvinskasFrancesco Neri
Nov 3, 2020·Clinical Colorectal Cancer·Manish PariharZelton Dave Sharp
Nov 20, 2020·Cell Death and Differentiation·Joep SprangersMadelon M Maurice
Dec 8, 2020·Frontiers in Cell and Developmental Biology·William D ReesTheodore S Steiner
Jan 29, 2021·Cell Death & Disease·Michaela QuinteroHonglin Li
Dec 5, 2020·Biomedicines·Yoojin SeoJeong-Seok Nam
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Elisabeth UrbauerDirk Haller
Jan 29, 2021·Stem Cells International·Viktoria HentschelMartin Müller
Feb 23, 2020·Cell Stem Cell·Kazutaka MurataRamesh A Shivdasani
Mar 7, 2021·Cancers·Romina Judith WalterLeonel Munoz-Sagredo
Mar 9, 2021·International Journal of Medical Microbiology : IJMM·Amina Iftekhar, Michael Sigal
Mar 7, 2021·Cancers·Marinella MarzanoMariangela De Robertis
Apr 30, 2021·Nature Reviews. Immunology·Mark Schmitt, Florian R Greten
May 11, 2020·Cell Stem Cell·Kara L McKinleyOphir D Klein
Sep 12, 2020·Current Opinion in Cell Biology·Yue Xing, Shruti Naik

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