Abstract
Pituitary metastasis occurs rarely in cancer patients and often remains undiagnosed. However, early detection and appropriate treatment can improve the patient's quality of life and possibly prolong survival. Herein, we describe the case of a 52-year-old woman with panhypopituitarism caused by metastases to the hypothalamus and pituitary from primary breast cancer. She had a 5-year history of breast cancer with metastases to the bones 1.5 years after initial diagnosis and mastectomy. She presented with severe headaches, generalized fatigue, dizziness, hypotension, difficulties with balance and coordination, polyuria, and polydipsia. Laboratory work-up revealed panhypopituitarism (central diabetes insipidus; hypothyroidism; and low prolactin, gonadotrophin, and adrenocorticotropic hormone levels), and magnetic resonance imaging confirmed the pituitary and hypothalamic involvement. She received hormone replacement therapy, radiation therapy of the sella turcica and suprasellar lesion, and chemotherapy, with significant improvement of her clinical status, but she died 15 months later.
References
Jul 1, 1975·Cancer·R J Teears, E M Silverman
Sep 1, 1992·Clinical Radiology·R ChaudhuriJ B Bingham
Oct 11, 1992·Mayo Clinic Proceedings·F MarinW F Young
Jan 1, 1989·British Journal of Neurosurgery·P C McCormickA P Hays
Nov 1, 1987·Radiology·N ColomboT H Newton
Jan 1, 1973·Oncology·K Kovacs
Sep 1, 1970·Cancer·W A HouckJ Horton
Feb 1, 1970·Cancer·U RoessmannR L Friede
Dec 15, 1983·Cancer·D W Kimmel, B P O'Neill
Aug 1, 1981·Neurology·M B MaxD A Rottenberg
Apr 1, 1981·Neurosurgery·O B LeramoT P Morley
Dec 1, 1993·Archives of Surgery·H L BumpersE D Holyoke
Jul 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Boogerd
Jul 1, 1998·Journal of Neurosurgery·A MoritaE R Laws
Oct 7, 1998·Journal of Neurosurgery·C S RumanaR Sawaya
Jan 5, 2002·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·J H ShinD G Na
Dec 10, 2002·Archives of Neurology·Robert J Weil
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John KomninosNicolas C Thalassinos
Jun 12, 2004·Neurosurgical Focus·Daniel R Fassett, William T Couldwell
Dec 9, 2004·Onkologie·I SturmB Dörken
Jul 2, 2005·International Journal of Clinical Oncology·Carla KurkjianMohamed A Kharfan-Dabaja
Citations
May 12, 2012·Case Reports in Medicine·Nestoras MathioudakisShehzad Basaria
Nov 30, 2014·Semergen·J GilL Cuéllar
May 27, 2010·Cancer Science·Haiming SunSongbin Fu
Jan 22, 2014·Pituitary·Wenzhuan HeJeremy D W Greenlee
Dec 18, 2013·Pituitary·Ribal Al-AridiBaha M Arafah
Aug 25, 2018·Endocrine Connections·Aida JavanbakhtBehrouz Salehian
Mar 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Salvatore Maria CorselloFrancesco Torino
Mar 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Fredrika SchillPia Burman
Mar 12, 2010·Journal of Korean Academy of Nursing·Eunok Park
Aug 15, 2017·Biomedical Reports·Tsutomu NamikawaKazuhiro Hanazaki
Nov 8, 2015·BMC Cancer·Tomoko TanakaYasunari Nakamoto
Aug 16, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ahmed MekkiSamy Ammari