Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature

Clinical Breast Cancer
Melpomeni PeppaDimitrios Hadjidakis

Abstract

Pituitary metastasis occurs rarely in cancer patients and often remains undiagnosed. However, early detection and appropriate treatment can improve the patient's quality of life and possibly prolong survival. Herein, we describe the case of a 52-year-old woman with panhypopituitarism caused by metastases to the hypothalamus and pituitary from primary breast cancer. She had a 5-year history of breast cancer with metastases to the bones 1.5 years after initial diagnosis and mastectomy. She presented with severe headaches, generalized fatigue, dizziness, hypotension, difficulties with balance and coordination, polyuria, and polydipsia. Laboratory work-up revealed panhypopituitarism (central diabetes insipidus; hypothyroidism; and low prolactin, gonadotrophin, and adrenocorticotropic hormone levels), and magnetic resonance imaging confirmed the pituitary and hypothalamic involvement. She received hormone replacement therapy, radiation therapy of the sella turcica and suprasellar lesion, and chemotherapy, with significant improvement of her clinical status, but she died 15 months later.

References

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Citations

May 12, 2012·Case Reports in Medicine·Nestoras MathioudakisShehzad Basaria
Aug 25, 2018·Endocrine Connections·Aida JavanbakhtBehrouz Salehian
Mar 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Salvatore Maria CorselloFrancesco Torino
Mar 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Fredrika SchillPia Burman
Aug 15, 2017·Biomedical Reports·Tsutomu NamikawaKazuhiro Hanazaki
Aug 16, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ahmed MekkiSamy Ammari

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