Panic disorder and social phobia: possible implications of comorbid depression for drug therapy

Anxiety
R B Lydiard

Abstract

Major depression is a common mental disorder with a lifetime prevalence of approximately 15% of the general population, affecting almost twice as many females as males. Panic disorder is a severe anxiety disorder with a lifetime prevalence of 2-3% or more. Like major depression, panic disorder affects nearly twice as many females as males. Both panic disorder and major depression are often chronic conditions, resulting in significant morbidity and mortality. Among patients who seek treatment for either panic disorder or major depression, both conditions are present in approximately one-third of the patient population. Substantial information suggests that individuals who suffer from both panic disorder and major depression respond poorly to acute treatment, are more likely to remain ill over the long term, require more psychiatric treatment, and are at approximately twice the risk of suicide attempts than individuals who suffer from either condition alone. There has been very little systematic study of individuals with coexisting panic disorder and major depression. This has left significant gaps in our knowledge about optimal treatment for the substantial subgroup of individuals suffering from both disorders simultaneously. So...Continue Reading

Citations

Oct 23, 2001·Depression and Anxiety·J LevineS Gershon
Dec 16, 1998·Journal of Affective Disorders·R B Lydiard
Nov 29, 2002·Human Psychopharmacology·Michel Bourin, Olivier Lambert
Apr 19, 2000·Journal of Clinical Psychopharmacology·P C HassanN Herrmann

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