Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy

Cancer Chemotherapy and Pharmacology
Richard J EpsteinPolly S Y Cheung

Abstract

The severity of chemotherapy-induced oral mucositis has previously been reported to be greater in patients who chew betel quid (areca), an addictive habit shared by hundreds of millions of individuals worldwide. Here, we report a case of fulminant panmucositis complicating dose-dense adjuvant breast cancer treatment in a betel-chewing patient without evidence of other risk factors. Grade IV mucositis was triggered by the initial use of standard-dose anthracycline chemotherapy, and involved not only the mouth but also the genital and anal mucosa, as well as other severe non-mucosal toxicities. Despite subsequent treatment with dose-reduced CMF and docetaxel regimens-which are seldom associated with mucosal toxicity at these dose intensities in the absence of neutropenia-high-grade oral mucositis continued to complicate the therapeutic course. These observations suggest that the potentiation of chemotherapy-induced mucositis by quid chewing may not be mediated solely by local effects on the oral epithelium, but also involves the systemic absorption of toxic chemosensitising molecules.

References

May 1, 1978·Mutation Research·G SadasivanC K Kumari
Mar 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H KitaniM M Elkind
May 1, 1995·Gynecologic Oncology·C GabelT W Burke
Jan 21, 1993·The New England Journal of Medicine·G P BrowmanM N Levine
Mar 30, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M F HaqueM Harris
Jun 1, 2001·Journal of Biomedical Science·N S Chu
Jul 26, 2002·Cell Proliferation·C L FarrellD L Lacey
Jan 10, 2003·Annals of Human Biology·S S StricklandA V Kurpad
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory M M VideticEdward W Yu
Jan 1, 2004·Journal of Public Health Dentistry·Chung-Jung ChiuChien-Jen Chen
Jan 30, 2004·Oral Oncology·Shanbeh ZienolddinyHiroshi Yamasaki
Jan 12, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang
Mar 4, 2005·Oral Oncology·Saman WarnakulasuriyaCrispian Scully
Apr 13, 2005·International Journal of Cancer. Journal International Du Cancer·Shu-Chun LinKuo-Wei Chang

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Citations

Jan 25, 2018·British Journal of Clinical Pharmacology·Charles AwortweBernd Rosenkranz
Oct 7, 2011·Attention, Perception & Psychophysics·Ming-Chou Ho, Chin-Kun Wang
Aug 27, 2021·Medicines·Mary Beth BabosPaul Herscu

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