Pannexins in vision, hearing, olfaction and taste

Neuroscience Letters
Paige Whyte-FagundesGeorg Zoidl

Abstract

In mammals, the pannexin gene family consists of three members (Panx1, 2, 3), which represent a class of integral membrane channel proteins sharing some structural features with chordate gap junction proteins, the connexins. Since their discovery in the early 21st century, pannexin expression has been detected throughout the vertebrate body including eye, ear, nose and tongue, making the investigation of the roles of this new class of channel protein in health and disease very appealing. The localization in sensory organs, coupled with unique channel properties and associations with major signaling pathways make Panx1, and its relative's, significant contributors for fundamental functions in sensory perception. Until recently, cell-based studies were at the forefront of pannexin research. Lately, the availability of mice with genetic ablation of pannexins opened new avenues for testing pannexin functions and behavioural phenotyping. Although we are only at the beginning of understanding the roles of pannexins in health and disease, this review summarizes recent advances in elucidating the various emerging roles pannexins play in sensory systems, with an emphasis on unresolved conflicts.

References

Feb 1, 1986·Archives of Ophthalmology·R D Sperduto, R Hiller
Feb 17, 2000·The New England Journal of Medicine·S L FineA C Ho
Jul 19, 2000·Current Biology : CB·Y PanchinS Lukyanov
Sep 12, 2000·The Journal of Comparative Neurology·C ZhangD Restrepo
Feb 20, 2002·Brain Research·Chunbo Zhang, Diego Restrepo
Apr 11, 2003·The Journal of Comparative Neurology·Chunbo Zhang, Diego Restrepo
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roberto BruzzoneHannah Monyer
Aug 12, 2004·FEBS Letters·Li BaoGerhard Dahl
Jun 1, 2005·Neuron·Jason M ChristieGary L Westbrook
Jul 20, 2005·The European Journal of Neuroscience·Arundhati RayRolf Dermietzel
Aug 17, 2005·PLoS Genetics·Richard T LibbySimon W M John
Sep 7, 2005·Brain Research. Molecular Brain Research·Angelika VogtHannah Monyer
Apr 18, 2006·FEBS Letters·Galina DvoriantchikovaValery I Shestopalov
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Silviu LocoveiGerhard Dahl
Jan 20, 2007·The EMBO Journal·Roman A RomanovStanislav S Kolesnikov
Jan 24, 2007·FEBS Letters·Silviu LocoveiGerhard Dahl
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yi-Jen HuangStephen D Roper
Sep 27, 2007·Ophthalmic Epidemiology·Ronald Klein
Jul 4, 2008·American Journal of Physiology. Cell Physiology·William SilvermanGerhard Dahl
Oct 24, 2008·American Journal of Physiology. Cell Physiology·Feng Qiu, Gerhard Dahl
Nov 15, 2008·The Journal of Comparative Neurology·Xiao-Hui WangHong-Bo Zhao
Nov 26, 2008·The Journal of General Physiology·Roman A RomanovStanislav S Kolesnikov
Feb 24, 2009·Trends in Neurosciences·Gary D HousleyAndreas Reichenbach
Apr 25, 2009·Current Opinion in Ophthalmology·Norman B Javitt, Jonathan C Javitt
May 7, 2009·The Journal of Biological Chemistry·William R SilvermanGerhard Dahl
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brady J MaherGary L Westbrook
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yijen A HuangStephen D Roper
Jun 4, 2010·Journal of Neurophysiology·Yoshihiro MurataYuzo Ninomiya
Jul 6, 2010·Experimental Eye Research·Huiling HuClaire H Mitchell
Jul 8, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Carla Mucignat-Caretta
Jul 29, 2010·Science Signaling·Moritz KronlagePeter J Hanley
Aug 13, 2011·Biochimica Et Biophysica Acta·R C Looft-WilsonB E Isakson
Aug 16, 2011·Neuroscience Research·Chunbo Zhang
Sep 17, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andreas Bringmann, Peter Wiedemann
Oct 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lisa RouxChristian Giaume
Feb 7, 2012·Biochimica Et Biophysica Acta·Silvia PenuelaDale W Laird
Mar 3, 2012·PloS One·Galina DvoriantchikovaValery I Shestopalov

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