PMID: 9545177Apr 17, 1998Paper

Panniculitis due to potassium bromide

Brain & Development
W DienerP A Berg

Abstract

Potassium bromide again is well known to be surprisingly effective in patients with severe myoclonic epilepsy in infants (SME). Rare side effects on the skin reappeared, such as the febrile nodular panniculitis (Weber-Christian syndrome). In 1993 we described the first three cases of necrotizing panniculitis and introduced the term 'halogen panniculitis'. It is a systemic disease with crops of subcutaneous nodules, fever, elevated sedimentation rate, hepatosplenomegalia, and abdominal pain. Later severe necrosis of the skin and adipose tissue may happen with deep ulcerations. History and course of five cases, described in this paper, suggest either an allergy or toxic reason. Histologic picture shows inflammation of adipose tissues with infiltrating lymphocytes, but lymphocyte transformation test (LTT) was not reliable in diagnosing the disease. Possibly, bromides act as a chemokine and stimulate inflammatory processes. Bromide can be transformed into a bromine radical/free electron pair under UV irradiation at 228.8 nm in aqueous solution. The bromine radical may have detrimental effects on the tissue. However, despite some research, the origin of halogen panniculitis and similar diseases remains unclear.

References

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Citations

Sep 16, 2004·Pediatric Blood & Cancer·Erol KismetAbdullah Avni Atay
May 21, 2009·Environmental Science & Technology·Yang-Won SuhGabriele Ludewig
Dec 12, 2012·Irish Veterinary Journal·Sonja SteinmetzHenning Christian Schenk
Oct 22, 2002·Journal of the American Veterinary Medical Association·Dawn Merton BoothePauline Couch
Mar 3, 2012·Journal of the American Veterinary Medical Association·Hope E Baird-HeinzLaura L Hungerford
Oct 5, 2007·Leukemia Research·O Meltem AkayZafer Gulbas
Mar 10, 2016·Journal of the American Veterinary Medical Association·Annalisa ForlaniPaola Roccabianca
Sep 13, 2005·The Veterinary Journal·Kate Chandler
Sep 17, 2013·The Journal of Small Animal Practice·N A Boynosky, L B Stokking
May 6, 2016·Frontiers in Veterinary Science·Tina KochAndrea Fischer
Apr 5, 2003·Analytical and Bioanalytical Chemistry·J F van StadenR I Stefan
Apr 13, 2012·Journal of Feline Medicine and Surgery·Coralie BertolaniAlexandra Gabriel
Jul 11, 2007·Journal of Child Neurology·Rudolf KorinthenbergJan Peter Ernst

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