PMID: 9164064Apr 1, 1997Paper

Panniculitis with eosinophilic infiltration due to gabexate mesilate (FOY): possibility of allergic reaction

The Journal of Dermatology
F Nakayama

Abstract

A 59-year-old Japanese man developed septal panniculitis with eosinophilic infiltration in both forearms and the dorsum of the left hand after a gabexate mesilate intravenous drip infusion for acute pancreatitis through catheters implanted in these sites. Gabexate mesilate at a dose of 1000 mg per day had been given continuously for 8 days, and antibiotics were added by the same infusion route twice a day. All the infusion routes, however, became occluded one after the other. Reddish swelling first occurred at the left wrist 6 hours after occlusion of the infusion route, and, on both forearms, reddish swelling occurred about one week after the occlusion of each route. Patch testing revealed a +2 reaction to gabexate mesilate (10% pet) at days 3 and 7, and skin testing revealed indurated erythema to gabexate mesilate (0.1% aq) at days 2 and 3. The specimens biopsied from the positive skin testing reaction sites showed perivascular infiltrate and slight septal panniculitis. The inflammatory infiltrate consisted predominantly of lymphocytes with small numbers of eosinophils. Staining of the specimen biopsied from the right forearm lesion with anti-eosinophil cationic protein (ECP) antibodies (EG1 and EG2) showed deposition of eosi...Continue Reading

Citations

Jan 10, 2008·The Journal of Dermatology·Takashi MiyakuraRyoji Tsuboi
Dec 23, 2006·International Journal of Dermatology·Y LiuT Jiao
May 9, 2001·Journal of Enzyme Inhibition·R FedericoP Ascenzi

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