PMID: 12756183May 21, 2003Paper

pannier and pointedP2 act sequentially to regulate Drosophila heart development

Development
Alejandra D AlvarezJ B Skeath

Abstract

The Drosophila heart consists of two major cell types: cardioblasts, which form the contractile tube of the heart; and pericardial cells, which flank the cardioblasts and are thought to filter and detoxify the blood or hemolymph of the fly. We present the completion of the entire cell lineage of all heart cells. Notably, we detect a previously unappreciated distinction between the lineages of heart cells located in the posterior seven segments relative to those located more anteriorly. Using a genetic screen, we have identified the ETS-transcription factor pointed as a key regulator of cardioblast and pericardial cell fates in the posterior seven segments of the heart. In this domain, pointed promotes pericardial cell development and opposes cardioblast development. We find that this function of pointed is carried out primarily if not exclusively by the pointedP2 isoform and, that in this context, pointedP2 may act independently of Ras/MAPK pathway activity. We go on to show that the GATA transcription factor pannier acts early in dorsal mesoderm development to promote the development of the cardiac mesoderm and thus all heart cells. Finally, we demonstrate that pannier acts upstream of pointed in a developmental pathway in whi...Continue Reading

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Citations

Dec 25, 2009·Pediatric Cardiology·Ingolf Reim, Manfred Frasch
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Monika ZmojdzianKrzysztof Jagla
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anwarul FerdousDaniel J Garry
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaochun MouIan Duncan
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sijun ZhuYuh-Nung Jan
Jun 6, 2009·Human Molecular Genetics·Li Qian, Rolf Bodmer
Oct 25, 2011·Nucleic Acids Research·Viviana Valadez-GrahamMario Zurita
Sep 6, 2007·Genes & Development·Simon G SprecherClaude Desplan
Sep 17, 2011·Circulation Research·Matthew J Wolf, Howard A Rockman
Oct 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Martina ZikovaKrzysztof Jagla
Aug 4, 2015·Journal of Cardiovascular Development and Disease·Georg Vogler, Rolf Bodmer
Oct 14, 2008·Biochimica Et Biophysica Acta·Anton L Bryantsev, Richard M Cripps
Dec 7, 2007·Gene Expression Patterns : GEP·Debjani DasManeesha Inamdar
Jan 9, 2007·Seminars in Cell & Developmental Biology·Ye Tao, Robert A Schulz
Dec 14, 2004·Genesis : the Journal of Genetics and Development·Dmitry Popichenko, Achim Paululat
Nov 23, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Volker Hartenstein, Lolitika Mandal
Mar 31, 2007·Cellular Microbiology·Michèle Crozatier, Marie Meister
Nov 26, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jae-Ryeon RyuWilliam J Brook
Nov 23, 2013·Genesis : the Journal of Genetics and Development·Min TangKaren Ocorr
Jan 22, 2005·Seminars in Cell & Developmental Biology·Richard Paul SorrentinoRobert A Schulz
Jul 21, 2004·Current Opinion in Genetics & Development·Eileen E Furlong
Mar 30, 2016·Journal of Applied Genetics·Elisa TassanoCristina Cuoco
Feb 24, 2007·Differentiation; Research in Biological Diversity·Tsuyoshi TokusumiRobert A Schulz
May 23, 2006·Mechanisms of Development·Stefanie AlbrechtAchim Paululat
Mar 20, 2012·Arthropod Structure & Development·Christine LehmacherAchim Paululat

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