Pantethine Prevents Murine Systemic Sclerosis Through the Inhibition of Microparticle Shedding

Arthritis & Rheumatology
Niloufar KavianFrédéric Batteux

Abstract

Endothelial cell (EC) damage in systemic sclerosis (SSc) is reflected by the shedding of microparticles (MPs). The aim of this study was to show that inhibiting MP release using pantethine or by inactivating ATP-binding cassette transporter A1 (ABCA1) ameliorates murine SSc. First, the effects of pantethine on MP shedding and on basal oxidative and nitrosative stresses in ECs and fibroblasts were determined in vitro. The effects of pantethine were then tested in vivo. SSc was induced in BALB/c mice by daily intradermal injection of HOCl. Mice were simultaneously treated daily with pantethine by oral gavage. In vitro, pantethine inhibited MP shedding from tumor necrosis factor-stimulated ECs and abrogated MP-induced oxidative and nitrosative stresses in ECs and fibroblasts. Ex vivo, pantethine also restored redox homeostasis in fibroblasts from mice with SSc. In vivo, mice with SSc displayed skin and lung fibrosis associated with increased levels of circulating MPs and markers of oxidative and endothelial stress, which were normalized by administration of pantethine or inactivation of ABCA1. Pantethine is a well-tolerated molecule that represents a potential treatment of human SSc.

References

Mar 1, 1992·The Journal of Pathology·R J PrescottP Fielding
Oct 1, 1985·The Journal of Clinical Investigation·C T WittwerJ G Thoene
Jan 1, 1984·Methods in Enzymology·H Aebi
Nov 15, 1994·European Journal of Biochemistry·G PitariS Duprè
May 23, 2001·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Aug 28, 2002·Diabetes·Florence SabatierFrancoise Dignat-George
Jan 6, 2005·The American Journal of Pathology·Valéry CombesGiovanna Chimini
May 10, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Alexandre MezentsevSergey V Brodsky
Apr 8, 2006·International Journal for Parasitology·Valéry CombesGeorges Emile Grau
Dec 21, 2006·Autoimmunity·Jörg H W DistlerDavid S Pisetsky
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie-France PenetBouchra Gharib
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·H Ahmed MostefaiM Carmen Martinez
Jun 13, 2008·Seminars in Immunopathology·Armando GabrielliEnrico V Avvedimento
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Hadj Ahmed MostefaiRamaroson Andriantsitohaina
Sep 6, 2008·The American Journal of Pathology·Abdelali AgouniRamaroson Andriantsitohaina
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amélie ServettazFrédéric Batteux
May 8, 2009·The New England Journal of Medicine·Armando GabrielliThomas Krieg
Aug 21, 2009·The New England Journal of Medicine·Jean-Baptiste DemoulinFredrik Rorsman
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anil RanaOdy C M Sibon
Aug 13, 2011·Cell Death & Disease·R CoriatF Batteux
Aug 20, 2011·Circulation Research·Pierre-Emmanuel RautouChantal M Boulanger
Apr 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niloufar KavianFrédéric Batteux

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Citations

Nov 13, 2015·Expert Review of Clinical Immunology·Mike O Becker, Gabriela Riemekasten
Jan 30, 2018·Frontiers in Neurology·Jordan Maximillian Wilkins, Eugenia Trushina
Sep 19, 2018·Free Radical Research·Paul R J AmesJose DelgadoAlves
Feb 20, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Fuki KawaguchiShinji Sasazaki
Jul 4, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kevin BarangerPhilippe Benech
Feb 1, 2020·Journal of Extracellular Vesicles·Mariadelva Catalano, Lorraine O'Driscoll
Jul 28, 2020·Rheumatology International·Bohdana DoskaliukOlena Zimba
Oct 1, 2020·International Journal of Molecular Sciences·Mohammed Tayab HussainLucy Victoria Norling
Nov 21, 2018·Life Science Alliance·Caroline GiessnerPhilippe Naquet
Sep 23, 2020·Pharmacology & Therapeutics·Maria Azparren-AnguloJuan M Falcon-Perez
May 1, 2021·International Journal of Molecular Sciences·Maja KosanovićMilica Bozic
Oct 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yujia HaoXing Wang

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