Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease.

The Journal of Infectious Diseases
Juliane Bubeck WardenburgFrank R DeLeo

Abstract

Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.

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Citations

Jan 6, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shawna F GravesFrank R DeLeo
Nov 15, 2011·Seminars in Immunopathology·Kevin M Rigby, Frank R DeLeo
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Aug 15, 2009·Nature Reviews. Microbiology·Henry F Chambers, Frank R Deleo
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Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Pauline Yoong, Gerald B Pier
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Binh An DiepHenry F Chambers
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