Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation

Free Radical Biology & Medicine
Vyacheslav S SlyshenkovLech Wojtczak

Abstract

Preincubation of Ehrlich ascites tumor cells at 22 or 32 degrees C, but not at 0 degree C, with pantothenic acid, 4'-phosphopantothenic acid, pantothenol, or pantethine reduced lipid peroxidation (measured by production of thiobarbituric acid-reactive compounds) induced by the Fenton reaction (Fe2+ + H2O2) and partly protected the plasma membrane against the leakiness to cytoplasmic proteins produced by the same reagent. Pantothenic acid and its derivatives did not inhibit (Fe2+ + H2O2)-induced peroxidation of phospholipid multilamellar vesicles, thus indicating that their effect on the cells was not due to the scavenging mechanism. Homopantothenic acid and its 4'-phosphate ester (which are not precursors of CoA) neither protected Ehrlich ascites tumor cells against lipid peroxidation nor prevented plasma membrane leakiness under the same conditions. Incubation of the cells with pantothenic acid, 4'-phosphopantothenic acid, pantothenol, or pantethine significantly increased the amount of cellular CoA and potentiated incorporation of added palmitate into phospholipids and cholesterol esters. It is concluded that pantothenic acid and its related compounds protect the plasma membrane of Ehrlich ascites tumor cells against the dama...Continue Reading

References

Jan 1, 1978·Biochemical Pharmacology·Y Masuda, T Murano
Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·A O KumerovaI Ia Shkestere
Jan 1, 1992·Journal of Studies on Alcohol·M C NewlandB Weiss
Jun 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·L Ia Utno
Jan 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·A O KumerovaL Ia Utno
Jan 1, 1989·Free Radical Biology & Medicine·I A ClarkW B Cowden
Jan 1, 1989·Free Radical Biology & Medicine·N J Schisler, S M Singh
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·A Sevanian, E Kim
Mar 1, 1985·The American Journal of Clinical Nutrition·M AprahamianJ F Grenier
Jan 31, 1972·European Journal of Biochemistry·J BremerS Skrede

❮ Previous
Next ❯

Citations

Sep 3, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Hilal ErmisZeynep Ayfer Aytemur
May 23, 2001·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Jun 2, 1998·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Feb 8, 2013·Journal of Endourology·Ramazan AltintasHakan Parlakpinar
Nov 14, 2012·Kidney & Blood Pressure Research·Ramazan AltintasGul Pelin Odabas
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ramazan OzdemirAhmet Karadag
Mar 16, 2016·Clinical and Experimental Otorhinolaryngology·Yuksel TopluAhmet Kizilay
Jan 31, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·E Naruta, V Buko
Mar 19, 2015·Journal of Pediatric Surgery·Ahmet KaradagAbdurrahman Karaman
May 16, 2017·The Journal of Dermatological Treatment·Ehrhardt ProkschStéphanie Boudon
Oct 16, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·B TutunE N Yasar
Apr 17, 2020·British Journal of Neurosurgery·Mehmet Fatih KorkmazErsoy Kekilli
Nov 25, 2016·Experimental and Therapeutic Medicine·Yasir Furkan CaginKevser Tanbek
Sep 25, 2020·International Journal of Molecular Sciences·Hee-Yeon JungJang-Hee Cho
Jan 5, 2019·BMC Complementary and Alternative Medicine·Manal F El-KhadragyAhmed E Abdel Moneim
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amany Abdel-Rahman MohamedHaytham A Ali

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.