Panvascular inflammation and mechanisms of injury in perioperative CNS outcomes

Seminars in Cardiothoracic and Vascular Anesthesia
John M Murkin

Abstract

In this review, the evidence for inflammatory processes as being of fundamental importance in end-organ dysfunction- specifically stroke and neurocognitive impairment in patients undergoing cardiac surgery-will be reviewed. The risk of central nervous system (CNS) impairment following an off-pump cardiac surgery will be contrasted with that of patients undergoing percutaneous coronary intervention (PCI) or medical management, and the role of progression of underlying cerebrovascular disease and, in particular, panvascular inflammation as an accompaniment to unstable angina with attendant risk of stroke will be explored. In addition, the various roles of preoperative comorbidities, aortic atheroma, and the use of selective avoidance of aortic instrumentation as well as carotid endarterectomy as risk modification strategies will be evaluated. Finally, a summary of recommendations for strategies to decrease risk of perioperative CNS impairment will be presented.

References

May 25, 1970·JAMA : the Journal of the American Medical Association·H M TufoR Shekelle
Feb 1, 1996·Stroke; a Journal of Cerebral Circulation·K H RyuF Dexter
Nov 5, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D L BairdD L Lee
Apr 12, 2000·Journal of the American College of Cardiology·M UraT Goto
Jul 26, 2000·Anesthesiology·C R EdmondsN E Sharrock
Sep 29, 2001·British Journal of Anaesthesia·K MillarG D Murray
Feb 2, 2002·Stroke; a Journal of Cerebral Circulation·Hilary P GrocottUNKNOWN Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators' of the Duke Heart Center
May 9, 2003·The Annals of Thoracic Surgery·Alexander A AlbertJürgen Ennker
Mar 16, 2004·Stroke; a Journal of Cerebral Circulation·Armin J GrauUNKNOWN CAPRIE Investigators
Jun 9, 2004·Circulation·Antonella LombardoAttilio Maseri
Mar 15, 2006·Current Opinion in Anaesthesiology·John M Murkin
Jul 11, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Victor AboyansMarc Laskar
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Per BergmanJan van der Linden
Sep 8, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Alberto RadaelliAlberto U Ferrari
Apr 22, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Silvana F MarascoMichael J Abramson
Dec 10, 2008·Neurobiology of Disease·Carla M WebsterMidori A Yenari
Feb 10, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A R NaylorP M Rothwell
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators

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Citations

Nov 3, 2012·International Psychogeriatrics·David A ScottLisbeth A Evered
Mar 5, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·John M Murkin, Mauricio Giraldo
Feb 26, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N M H BulowJ B T Rocha

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