Pap smears with glandular cell abnormalities: Are they detected by rapid prescreening?

Cancer Cytopathology
Yonca KanberManon Auger

Abstract

Rapid prescreening (RPS) is one of the quality assurance (QA) methods used in gynecologic cytology. The efficacy of RPS has been previously studied but mostly with respect to squamous lesions; in fact, there has been no study so far specifically looking at the sensitivity of RPS for detecting glandular cell abnormalities. A total of 80,565 Papanicolaou (Pap) smears underwent RPS during a 25-month period. A sample was designated as "review for abnormality" (R) if any abnormal cells (at the threshold of atypical squamous cells of undetermined significance/atypical glandular cells [AGC]) were thought to be present or was designated as negative (N) if none were detected. Each sample then underwent full screening (FS) and was designated as either R or N and also given a cytologic interpretation. The final cytologic interpretation was a glandular cell abnormality (≥AGC) in 107 samples (0.13%); 39 of these (36.4%) were flagged as R on RPS. Twenty-four patients (33.8%) out of 71 who had histologic follow-up were found to harbor a high-grade squamous intraepithelial lesion or carcinoma; 13 of those 24 Pap smears (54.2%) had been flagged as R on RPS. Notably, 11 AGC cases were picked up by RPS only and not by FS and represented false-neg...Continue Reading

References

Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Baker, D H Melcher
Jan 1, 1993·Cytopathology : Official Journal of the British Society for Clinical Cytology·C A Faraker
Jul 11, 1998·Cytopathology : Official Journal of the British Society for Clinical Cytology·C A Faraker
Jul 11, 2000·Diagnostic Cytopathology·S S Raab
Dec 29, 2000·Acta Cytologica·M Arbyn, U Schenck
Aug 8, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology·N DuddingS Rice
Aug 8, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology·C A Faraker
May 16, 2002·The Journal of Reproductive Medicine·Maya M HammoudRudi Ansbacher
Sep 25, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·D BrookeJ Sutton
Sep 27, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·J SmithR Deacon-Smith
Oct 19, 2004·American Journal of Clinical Pathology·David C ChhiengIsam Eltoum
Jun 22, 2005·Acta Cytologica·Rita Goreti AmaralEliana Borin Montemor
Oct 6, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A DanielW Faught
Feb 3, 2006·Acta Cytologica·Maria da Gloria Mattosinho de Castro FerrazAdhemar Longatta Filho
Mar 2, 2006·Obstetrics and Gynecology·Peter F SchnatzJoel I Sorosky
May 25, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·M PajtlerV Milicić-Juhas
Aug 11, 2006·Diagnostic Cytopathology·Reena Ramsaroop, Ien Chu
Oct 20, 2006·Journal of Lower Genital Tract Disease·Tung Van DinhEdward V Hannigan
Jun 19, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·A UllalV Wadehra
Aug 16, 2008·Acta Cytologica·Maria Lucia UtagawaAdhemar Longatto-Filho
Feb 12, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·A K AdhyaL K Dhaliwal
Nov 26, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·Giovanni Negri
Jan 15, 2013·Clinical Obstetrics and Gynecology·John O Schorge, Jose Alejandro Rauh-Hain
Mar 27, 2013·Journal of Lower Genital Tract Disease·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
May 3, 2013·Obstetrics and Gynecology·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference

❮ Previous
Next ❯

Citations

Jun 16, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·A H G TobiasC M Carneiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.