Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders.

Molecular Plant Pathology
Takayuki Shindo, Renier van der Hoorn

Abstract

Papain-like cysteine proteases (PLCPs) play crucial roles in plant-pathogen/pest interactions. During these parasitic interactions, PLCPs act on non-self substrates, provoking the selection of counteracting inhibitors and other means to evade proteolysis. We review examples of PLCPs acting on molecular battlefields in the extracellular space, plant cytoplasm and herbivore gut. Examples are maize Mir1 (Maize inbred resistance 1), tomato Rcr3 (Required for Cladosporium resistance-3), Pseudomonas AvrRpt2 and AurPphB, insect DvCAL1 (Diabrotica virgifera cathepsin L-like protease-1) and nematode MiCpl1 (Meloidogyne incognita cathepsin L-like protease 1). The data suggest that PLCPs cleave specific proteins and that their translocation, activation and inhibition of PLCPs are tightly regulated.

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Citations

Mar 6, 2013·Plant Molecular Biology·Ying-Bo MaoXiao-Ya Chen
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tolga O BozkurtSophien Kamoun
Mar 5, 2008·Plant Physiology·Keyan Zhu-SalzmanGary W Felton
May 3, 2008·The Plant Cell·Mohammed ShababRenier A L van der Hoorn
Apr 17, 2013·Antimicrobial Agents and Chemotherapy·Stephan ZindelHans-Lothar Fuchsbauer
Sep 26, 2015·International Journal of Molecular Sciences·Miklós PogányZoltán Bozsó
Apr 7, 2016·Medical Microbiology and Immunology·Mateusz KędziorJan Gutowicz
Nov 27, 2014·Frontiers in Plant Science·Remco StamGaëtan Thilliez
Sep 29, 2017·Frontiers in Plant Science·Mercedes Diaz-MendozaManuel Martinez
Jun 14, 2019·Frontiers in Plant Science·Manuel MartinezMercedes Diaz-Mendoza
Jun 21, 2014·The Plant Journal : for Cell and Molecular Biology·Bo ZhangHannele Tuominen
Oct 24, 2020·ELife·Robert GreenhalghMerijn R Kant

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