Papain-like cysteine proteases

Current Protocols in Protein Science
Dieter Brömme

Abstract

The name "cysteine protease" refers to the protease's nucleophilic cysteine residue that forms a covalent bond with the carbonyl group of the scissile peptide bond in substrates. The papain-like cysteine proteases, classified as the "C1 family" are the most predominant cysteine proteases. These proteases are found in viruses, plants, primitive parasites, invertebrates, and vertebrates alike. Mammalian papain-like cysteine proteases are also known as cathepsins. This unit discusses cathepsins, and their subcellular and tissue localization, catalytic mechanism, and substrate specificity. Several tables illustrate the properties of the various cathepsins.

References

Apr 1, 1977·European Journal of Biochemistry·H KirschkeP Bohley
May 1, 1986·The Biochemical Journal·D H RichA J Barrett
Jan 1, 1985·Calcified Tissue International·V EvertsW Beertsen
Apr 20, 1967·Biochemical and Biophysical Research Communications·I Schechter, A Berger
Oct 1, 1982·The Biochemical Journal·L Polgár, P Halász
Sep 15, 1995·The Journal of Biological Chemistry·I DolencV Turk
Jan 1, 1994·Methods in Enzymology·N D Rawlings, A J Barrett
Jan 1, 1994·Advances in Enzyme Regulation·N KatunumaT Saibara
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·E WeberH Kirschke
May 24, 1996·The Journal of Biological Chemistry·F H DrakeM Gowen
Apr 1, 1996·Protein Science : a Publication of the Protein Society·D Brömme, M E McGrath
Aug 1, 1996·Biological & Pharmaceutical Bulletin·K AibeK Honda
Nov 1, 1996·The Biochemical Journal·W P RenB F Sloane
Feb 1, 1997·Nature Structural Biology·M E McGrathD Brömme
Jan 1, 1997·Annual Review of Physiology·H A ChapmanG P Shi
Apr 11, 1997·The Journal of Biological Chemistry·N V RaoJ R Hoidal
Apr 1, 1997·Protein Science : a Publication of the Protein Society·C J LinneversD Brömme
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K ThompsonD F Veber
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·J DeussingJ A Villadangos
Jun 27, 1998·The Journal of Biological Chemistry·I SantamaríaC López-Otín
Jul 24, 1998·Biochemical and Biophysical Research Communications·T WexD Bromme
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P SaftigK von Figura
Nov 21, 1998·The Journal of Biological Chemistry·P GarneroJ M Delaissé
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·F BühlingT Welte
Jun 3, 1999·Bioorganic & Medicinal Chemistry·J H McKerrowC R Caffrey
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·C T Pham, T J Ley

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Citations

Apr 7, 2016·Medical Microbiology and Immunology·Mateusz KędziorJan Gutowicz
Mar 21, 2015·World Journal of Microbiology & Biotechnology·Chunfang LingAilin Tao
Jun 2, 2006·Electrophoresis·Mikko J LammiAnitta Mahonen
Dec 3, 2020·The Journal of Physical Chemistry. B·Gabriel OancaArieh Warshel
Dec 30, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·T A GureevaN I Solovyova

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