PMID: 11336322May 5, 2001Paper

Papillary carcinoma of the thyroid with distant metastases to the cerebrum: a case report

Japanese Journal of Clinical Oncology
T OtaM Fujisawa

Abstract

Cerebral metastases from papillary carcinoma of the thyroid are a very uncommon condition, but such metastases behave more aggressively and show poor prognosis. These metastases almost always involve concomitant lung or bone metastases which may be the first metastatic sites. Here we report a 53-year-old man with diffuse goiter and cervical lymphadenopathy who developed symptoms of elevated intracranial pressure. Computed tomography demonstrated ring-enhanced lesions showing a severe mass effect in the right cerebrum and a nodule in the right thyroid gland accompanied by swollen lymph nodes. Biopsied specimens of the thyroid nodule demonstrated malignant cells of papillary carcinoma. Surgical excision of the metastatic brain lesions was followed by total thyroidectomy with regional lymphadenectomy. Histological examinations confirmed that the patient had cerebral metastases from papillary carcinoma of the thyroid without other distant metastasis. Neurological abnormality disappeared after surgery and treatment with radioactive iodine (131I) and oral thyroxine were initiated thereafter. This case suggests that the thyroid gland is potentially a primary source of metastatic brain carcinoma. Moreover, early detection of cerebral m...Continue Reading

Citations

Jun 30, 2009·Head & Neck Oncology·Saleh Fahad Al-DhahriAbdullah Sulieman Terkawi
Aug 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Brahim El MostarchidMohammed Boucetta
Jun 26, 2012·BMJ Case Reports·Ali AkhavanHossein Navabii
May 11, 2010·Thyroid : Official Journal of the American Thyroid Association·Beatriz LecumberriLuis Felipe Pallardo
Apr 8, 2011·Cirugía española·Gonzalo Martín MartínJosé Vicente Roig Vila
Sep 26, 2012·Diagnostic Cytopathology·Jeff Wang, Yun Gong
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F M González ValverdeJ L Vázquez
Jan 18, 2006·Endocrine Journal·Kalliopi Pazaitou-PanayiotouIraklis Vainas
Mar 28, 2013·Virchows Archiv : an International Journal of Pathology·Farnaz C TahmasebiJian Yi Li

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