Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants.

Endocrine Pathology
Alfred King-Yin LamKaren Siu-Ling Lam

Abstract

Many histological variants of PTC have been described and some are known to have prognostic significance. However, their relative frequencies and associated clinicopathological features in a large cohort of patients with PTC treated at a single institution have seldom been documented. We reclassified 1035 malignant thyroid tumors treated in a 30-yr study period, into variants of PTC according to current histological criteria and analyzed their features. Six hundred and fifty two patients (153 men; 499 women) with PTC were identified. PTC accounted for 72.8% of primary thyroid cancers. Conventional papillary carcinoma (n = 300) accounted for 46% of PTC and papillary microcarcinoma 27.8% (n = 181). The frequencies of the common histological variants were follicular (17.6%, n =115), tall cell (4%, n = 26), and diffuse sclerosing (1.8%, n = 12). Uncommon histological variants including solid (n = 5), diffuse follicular (n = 5), papillary carcinoma with focal insular component (n = 3), columnar cell (n = 2), papillary carcinoma with fasciitis-like stroma (n = 2), and oncocytic (n = 1) were also noted. Histological variants of PTC had different age presentation, tumor size, frequencies of lymph node metastases, calcification, metapla...Continue Reading

Citations

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