Papillary glioneuronal tumor with minigemistocytic components and increased proliferative activity

Human Pathology
Takashi IshizawaTakanori Hirose

Abstract

Papillary glioneuronal tumor (PGNT) is a rare and new type of glioneuronal neoplasm of the central nervous system. It is characterized by pseudopapillary structures composed of hyalinized vessels rimmed by cuboidal glial cells and the proliferation of neuronal cells. We report a peculiar PGNT arising in the parietal lobe of a 67-year-old man, which was characterized by proliferation of minigemistocytic cells as well as typical components. The minigemistocytic cells had eccentric nuclei and plump eosinophilic cytoplasm that was filled with glial filaments. The Ki-67 labeling index was as high as 10% in the minigemistocytic areas. Recently, the presence of oligodendroglial-like component was suggested in PGNT. Considering that oligodendroglioma sometimes accompanies minigemistocytic components, the minigemistocytic cells in PGNT were suggested to be a part of oligodendroglial differentiation. Although PGNT is defined as an indolent glioneuronal tumor, the presence of minigemistocytic components with the high Ki-67 labeling index may indicate more aggressive nature.

References

Oct 20, 1998·The American Journal of Surgical Pathology·T KomoriM Kobayashi
Dec 2, 2000·Archives of Pathology & Laboratory Medicine·R A Prayson
Nov 29, 2002·Brain Tumor Pathology·Choutatsu Tsukayama, Yoshiki Arakawa
Mar 8, 2003·Brain Tumor Pathology·Roger E McLendon, James Provenzale
Apr 2, 2004·Journal of Neuropathology and Experimental Neurology·Giovanna Cenacchi, Felice Giangaspero
Apr 28, 2004·The American Journal of Pathology·Hideaki YokooYoichi Nakazato

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Citations

May 1, 2009·Journal of Neuro-oncology·Aparna GovindanS K Shankar
Feb 10, 2007·Diagnostic Pathology·B D RadotraSandeep Mohindra
Jan 6, 2009·Journal of Neurosurgery. Pediatrics·Ramin J JavaheryJ Gordon McComb
Feb 24, 2016·Acta neurochirurgica·Rui-Jiao ZhaoYin Wang
Jun 22, 2012·Clinical Neurology and Neurosurgery·Mohammed BenzagmoutLaurent Capelle
Aug 17, 2010·Neuroimaging Clinics of North America·Clare H CunliffeMary E Fowkes
Feb 17, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hema MahajanThomas Ng
Apr 9, 2014·Journal of Neuropathology and Experimental Neurology·Eric C BourekasHerbert B Newton
Mar 25, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hui XiaoQiuping Gui
Apr 14, 2012·Brain Pathology·Maria ThomEleonora Aronica
Mar 18, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Thotadamane Nagaraja ChandrashekharSusarla Krishna Shankar
Apr 18, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hiroyuki MomotaToshihiko Wakabayashi
Dec 23, 2008·Advances in Anatomic Pathology·Daniela S Allende, Richard A Prayson
Feb 8, 2007·Journal of Neuro-oncology·Jesús Vaquero, Santiago Coca
Oct 25, 2011·The American Journal of Surgical Pathology·Jae Kyung MyungSung-Hye Park
Apr 2, 2008·Journal of Computer Assisted Tomography·Shiori AmemiyaKuni Ohtomo
Aug 8, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shipra AgarwalP Sharat Chandra
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ellen GelpiHerbert Budka

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