Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma

Human Pathology
P TrivijitsilpC P Crum

Abstract

Papillary immature metaplasia (PIM) is a variant of human papillomavirus (HPV) 6 or 11 infection. PIM resembles an immature metaplasia but has filiform papillae, variable cytological atypia, and, frequently, extension into the endocervical canal. Because the unusual morphology and presentation of PIM may cause confusion between this and other benign and malignant papillary neoplasms, we conducted a clinicopathologic analysis of PIM and compared expression of Ki-67 between PIM, condyloma, and papillary carcinoma. Data on patient age, duration of the lesions, and procedures, including cone biopsy, were obtained. The distribution and intensity of staining for Ki-67 in the epithelium was recorded and compared with both condyloma and papillary carcinoma. HPV typing was performed by polymerase chain reaction (PCR) and restriction fragment length pleomorphism analysis (RFLP). Ten of 13 PIMs were HPV 6/11 positive. Three cases contained areas closely resembling condyloma. Eleven cone biopsies were performed on nine cases. Three were found to have a coexisting high-grade squamous intraepithelial lesion that was either HPV 6/11 negative or contained another HPV type. All PIMs displayed variable staining for Ki-67 with a low index of stai...Continue Reading

Citations

May 3, 2003·Virchows Archiv : an International Journal of Pathology·Socorro María Rodríguez-PinillaMaría Teresa Férnandez-Figueras
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C P Crum
Jun 23, 2000·Clinical Obstetrics and Gynecology·A P Pinto, C P Crum
Jan 2, 2007·Advances in Anatomic Pathology·Marisa R Nucci, Christopher P Crum
Jan 4, 2013·The American Journal of Surgical Pathology·Carlos Parra-HerranMarisa R Nucci
Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Christopher P Crum
Nov 10, 2015·The American Journal of Surgical Pathology·Jennifer M RobertsAnnabelle Farnsworth
Oct 13, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martina Z LiuChristopher P Crum
Nov 2, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sharon B Sams, Julie A Rosser

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