PMID: 5454357Sep 5, 1970Paper

Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures

British Medical Journal
R S Nanra, P Kincaid-Smith

Abstract

Nearly half the rats gavage-fed with aspirin and aspirin-containing mixtures developed papillary necrosis in 20 weeks. This incidence is similar to that found in rats on A.P.C. mixtures with high and low concentrations of p-chloracetanilide, an impurity of phenacetin. Aspirin alone produced necrosis in 7 out of 19 rats (36.8%) whereas phenacetin in the same dose had failed to cause any renal damage over six to nine months. If these results also apply to man they suggest that aspirin and not phenacetin may be the major factor in analgesic nephropathy in patients taking A.P.C. mixtures. An augmented clearance of aspirin appeared to afford some protection to the medulla, and it is suggested that this observation may have important clinical and epidemiological applications.

References

Jun 1, 1966·The Journal of Pharmacy and Pharmacology·L F Prescott
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D M Brown, T L Hardy
Jul 1, 1968·Annals of the Rheumatic Diseases·R J BulgerP Polinsky
Jan 18, 1969·British Medical Journal·B M Saker, P Kincaid-Smith
Jan 1, 1965·Nephron·C BrunA W Sorensen
May 1, 1959·Toxicology·E M BOYD
Mar 12, 1960·Lancet·K L GRANVILLE-GROSSMAN, H G SERGEANT
Dec 1, 1962·Annals of Internal Medicine·G E SCHREINER
Feb 16, 1963·Lancet·J T SCOTTJ DORLING
Oct 1, 1963·The American Journal of Medicine·B HARVALD
Feb 1, 1964·The American Journal of Medicine·A GILMAN
May 1, 1964·The American Journal of Medicine·K THURAU
Feb 6, 1960·Lancet·B HARVALDA NIELSEN
Oct 1, 1959·The Journal of Pathology and Bacteriology·H L SHEEHAN, J C DAVIS

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Citations

Oct 1, 1984·Bulletin of Environmental Contamination and Toxicology·L W FaulknerJ M King
Oct 1, 1986·Toxicology and Applied Pharmacology·S L JohanssonS M Cohen
Feb 1, 1976·Urology·P H ArgerM Goldberg
May 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W W Carlton, J A Engelhardt
Jan 1, 1977·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·A L TonkinR V Baudinette
Dec 1, 1992·Toxicology Letters·T OkamuraS M Cohen
Dec 1, 1973·Australian and New Zealand Journal of Medicine·R S NanraP Kincaid-Smith
Oct 1, 1976·Australian and New Zealand Journal of Medicine·J H Stewart, E D Gallery
Jan 1, 1976·Australian and New Zealand Journal of Medicine·R S Nanra
Jan 1, 1976·Australian and New Zealand Journal of Medicine·B M PhillipsH L Gurtoo
Jan 1, 1976·Australian and New Zealand Journal of Medicine·L F Prescott
Feb 27, 1971·British Medical Journal·R M MurrayA L Linton
Mar 6, 1971·British Medical Journal·M J KendallC F Hawkins
Mar 27, 1971·British Medical Journal·L Beeley, M J Kendall
Mar 30, 1974·British Medical Journal·A F MacklonD N Kerr
Apr 10, 1971·British Medical Journal·O M EdwardsR T Taylor
Jun 1, 1974·British Medical Journal
Dec 10, 1977·British Medical Journal·R Gokal, D R Matthews
Jul 21, 1973·British Medical Journal
Sep 22, 1973·British Medical Journal·I C CalderJ D Tange
Oct 17, 1970·British Medical Journal
Nov 27, 1971·British Medical Journal·I C CalderJ D Tange
Oct 21, 1972·British Medical Journal·R M Murray
Dec 29, 1973·British Medical Journal·R A Axelsen, A F Burry
Jan 5, 1987·Klinische Wochenschrift·A Schwarz
Jan 1, 1985·CRC Critical Reviews in Toxicology·P H Bach, J W Bridges
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Jan 1, 1980·Drug and Chemical Toxicology·A W Macklin, R J Szot
Jan 1, 1978·Current Medical Research and Opinion·P A Dieppe
Mar 1, 1976·Journal of Pharmaceutical Sciences·J L LeelingR L Kowalski
Jan 1, 1978·Kidney International·E A Molland
Jan 1, 1978·Kidney International·J H Shelley
Nov 14, 1983·The American Journal of Medicine·R S Nanra
Dec 1, 1971·The American Journal of Medicine·M H GaultR C Muehrcke
Oct 1, 1980·British Journal of Clinical Pharmacology·R A Axelsen
Jul 1, 1980·The Journal of Pediatrics·D W WortmannJ T Cassidy
Oct 1, 1974·Clinical Radiology·W S Hare, J D Poynter
Jun 14, 1983·The American Journal of Medicine·R D Emkey
Jul 1, 1972·Pathology·R A Axelsen, A F Burry

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