Papillary neuroepithelial tumor of the pineal region. A case report

Acta Neuropathologica
Junji ShibaharaMasashi Fukayama

Abstract

We present here an unusual case of papillary neuroepithelial tumor of the pineal region. The patient was a 29-year-old female who presented with headaches. A computed tomography scan revealed a tumorous lesion at the pineal region and hydrocephalus. The resected tumor was composed of columnar and cuboidal cells showing characteristics of papillary growth. The tumor cells exhibited diffuse and intense immunoreactivity to cytokeratins and neural cell adhesion molecule. The tumor expressed abundant levels of transthyretin (prealbumin) and appeared ependymal in nature, with numerous microlumens delineated by punctate and ring-like patterns in epithelial membrane antigen staining. Reactivity to synaptophysin and glial fibrillary acidic protein was observed only in the infiltrated non-neoplastic pineal parenchyma. These histological characteristics matched the description of the recently reported papillary tumor of the pineal region thought to originate from the specialized ependyma of the subcommissural organ (SCO). Transthyretin expression of the present case further supports the likelihood of SCO origin, as transthyretin is one of the proteins presumed to be secreted by human SCO.

References

Sep 1, 1990·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·E SchijmanT Tomita
Jul 1, 1990·Journal of Neurosurgery·J VaqueroJ Escandón
Nov 1, 1984·Surgical Neurology·J I AusmanS Patel
Nov 1, 1982·Cancer·J Q TrojanowskiL B Rorke
Oct 1, 1996·Journal of Korean Medical Science·S H ParkJ G Chi
Mar 8, 2000·International Journal of Radiation Oncology, Biology, Physics·F FauchonE Bouffet
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·K D VegeB W Scheithauer
Mar 10, 2001·Microscopy Research and Technique·E M RodríguezH Montecinos
Mar 22, 2003·Surgical Neurology·Stefan Nikolaus KroppenstedtRobert F Spetzler
Mar 27, 2003·The American Journal of Surgical Pathology·Anne JouvetMichelle Fèvre-Montange
Aug 5, 2003·Acta Neuropathologica·Martin Hasselblatt, Werner Paulus

❮ Previous
Next ❯

Citations

Oct 26, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kévin BuffenoirAntoine Listrat
Nov 7, 2008·Brain Tumor Pathology·Tomoo InoueTeiji Tominaga
Apr 3, 2012·Brain Tumor Pathology·Atsushi IshidaTomokatsu Hori
Nov 30, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A SantoroM Salvati
May 7, 2009·The American Journal of Surgical Pathology·Bret MobleyHannes Vogel
Dec 12, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tibor BocoElizabeth Cochran
Apr 16, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Michelle Fèvre-MontangeAnne Jouvet
Jul 1, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Winny VarikattThomas Ng
Apr 9, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yong Hwy KimSung-Hye Park
Dec 27, 2007·Neurologia Medico-chirurgica·Ichiro KawaharaTomayoshi Hayashi
May 15, 2010·Future Oncology·Michelle Fèvre-MontangeAnne Jouvet
Aug 11, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Wiesław MarcolMarcin Roszkowski
Jun 2, 2011·Brain Tumor Pathology·Gerival Vieira JúniorAtos Alves de Sousa
Dec 3, 2014·Neurologia i neurochirurgia polska·Andrzej KoziarskiEwa Skrobowska
Oct 11, 2007·AJNR. American Journal of Neuroradiology·A H ChangB L Dean
Sep 25, 2007·British Journal of Neurosurgery·T SantariusR W Kirollos
Mar 18, 2008·Journal of Neuropathology and Experimental Neurology·Norman L Lehman
Aug 16, 2011·World Neurosurgery·Martin LorenzettiManuela Caroli
Jun 11, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Katherine PoulgrainQueenie Lau
Aug 17, 2010·Neuroimaging Clinics of North America·Clare H CunliffeMary E Fowkes
Apr 8, 2006·Neuropathology and Applied Neurobiology·K KuchelmeisterW Schachenmayr
Apr 28, 2006·Neuropathology and Applied Neurobiology·M HasselblattW Paulus
Oct 15, 2010·Neuropathology and Applied Neurobiology·E Lechapt-ZalcmanA Jouvet
Mar 1, 2012·Brain Pathology·Yuen Shan WongWai-Sang Poon
Apr 8, 2011·Brain Pathology·Angelika GutenbergLaszlo Füzesi
Oct 17, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·J DhillonG N Fuller
May 3, 2011·Journal of Neurosurgery. Pediatrics·Jessica LiViolette Renard Recinos
Oct 23, 2010·Advances in Anatomic Pathology·Sonika Dahiya, Arie Perry
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Michelle Fèvre-MontangeJoël Lachuer
Jun 6, 2008·Surgical and Radiologic Anatomy : SRA·Bo SunShu Wei Liu
Apr 2, 2008·Journal of Computer Assisted Tomography·Shiori AmemiyaKuni Ohtomo
Oct 6, 2006·Journal of Neuropathology and Experimental Neurology·Michelle Fèvre-MontangeAnne Jouvet
May 17, 2012·The American Journal of Surgical Pathology·Michelle Fèvre MontangeAnne Jouvet
May 11, 2010·Journal of Neuro-oncology·Gentian KaloshiMentor Petrela
Apr 17, 2019·Neurosurgery·Vitor Nagai YamakiEberval Gadelha Figueiredo
Apr 4, 2021·Cancers·Gaia FaveroRita Rezzani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

The American Journal of Surgical Pathology
Anne JouvetMichelle Fèvre-Montange
Neurologia Medico-chirurgica
Ichiro KawaharaTomayoshi Hayashi
© 2022 Meta ULC. All rights reserved