Abstract
The present of malignant transformation in struma ovarii is exceedingly rare. Malignant struma ovarii is usually asymptomatic and infrequently diagnosed preoperatively. Because of its rarity, there is no consensus about diagnosis and management in the literature. A 40-year-old female presented for her obstetric examination with an incidental finding of a pelvic mass. Patient was asymptomatic at presentation. A follow-up ultrasound confirmed the presence of a 3-cm mass in the left adnexa. Patient underwent a cytoreductive surgery (hysterectomy, bilateral salpingectomy and oophorectomy, omentectomy, appendectomy, and pelvic lymphadenectomy). Histopathology revealed a malignant struma ovarii with a focus of papillary thyroid carcinoma and the omentum metastasis. The patient with stage FIGO IIIc received 6 cycles of paclitaxel/carboplatin regimen after surgery. The patient subsequently had a thyroid scan that was normal with normal thyroid function. At a follow-up of 12 months, she is alive, in good clinical condition, and disease-free. Because of the rarity of these tumors and their lack of firm prognostic factors, treatment decisions should be made individually, based on pathologic and clinical parameters.
References
Jan 1, 1990·Journal of Surgical Oncology·A ZakhemP Salem
Feb 1, 1989·Gynecologic Oncology·N G RosenblumJ J Mikuta
Jul 15, 1987·Cancer·P H WillemseH Doorenbos
Mar 1, 1970·Human Pathology·R E Scully
Jan 1, 1995·The American Journal of Surgical Pathology·W M SzyfelbeinR E Scully
Oct 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K DevaneyF A Tavassoli
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CulineJ P Droz
Aug 25, 2001·Gynecologic Oncology·K MatsudaK Kanazawa
Nov 10, 2001·The Medical Journal of Australia·S W Chan, K E Farrell
Aug 13, 2002·Pathology Oncology Research : POR·Fevziye KabukcuogluIsmail Evren
May 15, 2003·Endocrine Pathology·Mary B CaseyRicardo V Lloyd
Jun 12, 2003·Gynecologic Oncology·Christopher P DeSimoneSusan C Modesitt
Feb 20, 2007·Endocrine Pathology·Nobuki NakamuraRicardo V Lloyd
Aug 28, 2007·The American Journal of Surgical Pathology·Jason SchmidtVânia Nosé
Sep 21, 2007·Archives of Gynecology and Obstetrics·Melike DoganayLeyla Mollamahmutoglu
Aug 22, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Stanley J RobboyRobert H Young
Feb 1, 2012·Archives of Pathology & Laboratory Medicine·Ruthy Shaco-LevyStanley J Robboy
Nov 7, 2014·Thyroid : Official Journal of the American Thyroid Association·Paolo GoffredoJulie Ann Sosa
Citations
Jun 16, 2017·Clinical Medicine Insights. Endocrinology and Diabetes·Maria M PineyroRaul Pisabarro
Dec 22, 2017·Journal of the Endocrine Society·Roeland J W MiddelbeekJohanna A Pallotta
Feb 12, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Khatuna KhatchapuridzeDimitri Kordzaia
Sep 23, 2020·ANZ Journal of Surgery·Jaime López-SánchezLuis Muñoz-Bellvís
Nov 5, 2019·Archives of Gynecology and Obstetrics·Molly R SiegelBiftu M Mengesha
Jul 7, 2016·The American Journal of Case Reports·Stavros Diavatis, Alexis Papanikolaou
Mar 16, 2018·Oncology Letters·Lihua HuangLijiang Liu
May 4, 2021·BMC Pregnancy and Childbirth·Zheng LiQian Chen
Jul 6, 2021·The Journal of Obstetrics and Gynaecology Research·Sevgi AyhanGunsu Kimyon Comert
Nov 30, 2018·Case Reports in Oncology·Nobuko YasutakeTakuji Fujita