Papilledema: are we any nearer to a consensus on pathogenesis and treatment?

Current Neurology and Neuroscience Reports
Andrew G Lee, Michael Wall

Abstract

Papilledema is a term generally reserved (at least in the English language use of the term) by neuro-ophthalmologists for optic disc edema due to increased intracranial pressure. The etiology for the intracranial hypertension may be known (e.g., brain tumor, meningitis, cerebral venous sinus thrombosis) or may be idiopathic (idiopathic intracranial hypertension [IIH]). IIH is a disorder that predominantly affects overweight women of childbearing age and these epidemiologic factors should offer clues to pathogenesis. The main morbidity of papilledema is visual loss and the major mechanism for permanent optic nerve damage is axoplasmic flow stasis and resultant intraneuronal ischemia. The current initial management of papilledema in IIH includes weight loss and medical therapy (e.g., acetazolamide or furosemide). Patients who fail, are intolerant to, or noncompliant with maximum tolerated medical therapy might require optic nerve sheath fenestration or cerebrospinal fluid diversion (i.e., shunting) procedures.

References

Sep 1, 1977·Archives of Ophthalmology·S S Hayreh
May 1, 1979·Experimental Eye Research·S S HayrehD R Anderson
Aug 1, 1978·Journal of Neurosurgery·G Gücer, L Viernstein
May 1, 1975·Medicine·L A Weisberg
May 1, 1992·Archives of Ophthalmology·L M HamedN J Schatz
Dec 1, 1991·Brain : a Journal of Neurology·L D KartsounisJ R Bartlett
Aug 15, 1991·American Journal of Ophthalmology·T C SpoorM J Wilkinson
Nov 1, 1990·Australian and New Zealand Journal of Ophthalmology·R C SergottT M Bosley
May 1, 1990·Archives of Ophthalmology·K W To, F A Warren
Oct 1, 1988·Archives of Ophthalmology·N D BrourmanJ M Ramocki
Jan 1, 1986·International Ophthalmology Clinics·C H Smith, J C Orcutt
May 1, 1974·Archives of Internal Medicine·B Newborg
Jan 1, 1984·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·S S Hayreh
Nov 1, 1984·Ophthalmology·J C OrcuttM D Sanders
Nov 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J Corbett
Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·F GrehnG Kommerell
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J F AchesonM D Sanders
Jun 1, 1993·Neurology·M L RosenbergN Schatz
May 1, 1993·Archives of Ophthalmology·T C Spoor, J G McHenry
Jun 1, 1996·Neurology·E R EggenbergerS Vitale
Sep 26, 1997·Neurology·R A BurgettA Kawasaki
Feb 1, 1961·Medicine·R PATERSONS MANN
Nov 28, 2009·AJNR. American Journal of Neuroradiology·M BussièreD Pelz
Jul 20, 2010·Neurologic Clinics·Michael Wall
Sep 21, 2010·Journal of Neurology·Maren SkauRigmor Jensen

❮ Previous
Next ❯

Citations

Feb 2, 2013·Survey of Ophthalmology·Giovanni TaibbiGianmarco Vizzeri
Oct 4, 2014·International Forum of Allergy & Rhinology·Yanjun J XieDouglas D Reh
Oct 16, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jaclyn ChiangBarbara Zangerl
Aug 15, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Timothy J McCulleyW Jordan Piluek
Jan 13, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Benjamin D ElderDaniele Rigamonti
May 14, 2016·Journal of Neurosurgery. Pediatrics·Richard HaywardOwase Jeelani
Oct 16, 2016·Emergency Medicine Clinics of North America·Ramin R Tabatabai, Stuart P Swadron
Dec 27, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y Huang-LinkY-P Jin
Nov 16, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Jason C ParkJ Jason McAnany
Apr 3, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Amanda EdgarCraig Woods
Dec 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jennifer MurdockWendy W Lee
Feb 25, 2014·Neuro-ophthalmology·Eric HamillAndrew G Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.