PMID: 7541848Aug 1, 1995Paper

Papillomavirus L1 capsids agglutinate mouse erythrocytes through a proteinaceous receptor

Journal of Virology
R B RodenJ T Schiller

Abstract

Virus-like particles (VLPs) composed of L1 derived from bovine papillomavirus type 1 (BPV-1), several human papillomavirus types, or cottontail rabbit papillomavirus (CRPV) agglutinated mouse but not human or rat erythrocytes. Treatment of mouse erythrocytes with trypsin prevented hemagglutination (HA) by BPV-1. Sera from rabbits immunized with native CRPV VLPs, which protect against experimental CRPV infection, exhibited high titers of antibodies that inhibited CRPV VLP HA activity, while sera from rabbits immunized with denatured CRPV VLPs or native BPV VLPs, which do not protect against CRPV infection, were not inhibitory. Testing for HA inhibition is a rapid and simple method for examining the serological relatedness of papillomaviruses and measuring protective antibody titers after VLP vaccination.

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Citations

Apr 20, 2001·International Immunology·D M Da SilvaW M Kast
Feb 28, 2015·Pathogens and Disease·Zahra KianmehrFatemeh Fotouhi
Mar 7, 2020·Frontiers in Immunology·Anna Rosa GarbugliaPaola Del Porto
Dec 1, 1996·Genitourinary Medicine·I H Frazer
May 8, 2009·Immunology and Cell Biology·Balasubramanyam KaranamRichard B S Roden
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·H L GreenstoneJ T Schiller
May 2, 2015·Immunologic Research·Mohammed WahiduzzamanNeeta Singh
Feb 2, 2010·Expert Reviews in Molecular Medicine·Allison H Bartlett, Pyong Woo Park
Nov 20, 2002·Journal of Virology·Rika KomagomeKazuo Nagashima
Mar 1, 2003·Journal of Virology·Rongcun YangRichard B S Roden
Jul 21, 1997·Virology·M MüllerL Gissmann
Mar 14, 2000·Seminars in Cancer Biology·F Breitburd, P Coursaget

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