PAPP-A and cancer

Journal of Molecular Endocrinology
Cheryl A Conover, Claus Oxvig

Abstract

The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.

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Citations

Sep 10, 2020·Journal of Mammary Gland Biology and Neoplasia·Edmund Charles JenkinsDoris Germain
Jun 8, 2018·Journal of Molecular Endocrinology·Emily Jane Gallagher, Derek LeRoith
Sep 29, 2020·Frontiers in Endocrinology·Rikke HjortebjergJan Frystyk
Jul 22, 2020·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan FrystykRikke Hjortebjerg
May 8, 2021·Molecular Metabolism·Derek LeRoithBriony E Forbes
Aug 27, 2021·Experimental and Therapeutic Medicine·Virgiliu-Bogdan SoropMonica Susan

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