PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis

American Journal of Obstetrics and Gynecology
Nick A BersingerMichael D Mueller

Abstract

The purpose of this study was to evaluate whether pregnancy-associated plasma protein A, glycodelin, osteoprotegerin, and soluble CD163 are possible peritoneal fluid markers for endometriosis and to compare them with the established chemokine markers interleukin-8 and regulated on activation, normal T-cell expressed and secreted. Determination of the concentrations of interleukin-8, regulated on activation, normal T-cell expressed and secreted, pregnancy-associated plasma protein A, glycodelin, CD163, osteoprotegerin, and progesterone in the peritoneal fluid collected from women undergoing laparoscopy. From a total of 132 women, 77 women were diagnosed with endometriosis, and 55 women were free of the disease and served as control subjects. Pregnancy-associated plasma protein A and osteoprotegerin showed significantly (P < 0.05) elevated peritoneal fluid concentrations as a function of the severity of the disease, together with interleukin-8 and regulated on activation, normal T-cell expressed and secreted (P < .001). Glycodelin and CD163 did not differ between cases and control subjects. Many of these marker concentrations were intercorrelated strongly. Pregnancy-associated plasma protein A and osteoprotegerin may play a role ...Continue Reading

References

Feb 1, 1991·British Journal of Obstetrics and Gynaecology·T A Mahmood, A Templeton
Mar 1, 1980·British Journal of Obstetrics and Gynaecology·P R KoninckxI A Brosens
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J B LawrenceC A Conover
Apr 14, 2000·American Journal of Obstetrics and Gynecology·R N TaylorM D Mueller
Feb 13, 2001·Fertility and Sterility·D I LebovicR N Taylor
Apr 13, 2001·Seminars in Reproductive Medicine·M D MuellerR N Taylor
May 27, 2003·American Journal of Reproductive Immunology : AJRI·Aydin AriciNeal G Mahutte
Mar 24, 2006·Acta Obstetricia Et Gynecologica Scandinavica·Dorothea M WunderNick A Bersinger

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Citations

Feb 23, 2013·Archives of Gynecology and Obstetrics·Arif Kokcu
Jul 21, 2007·Gynäkologisch-geburtshilfliche Rundschau·Corinne Neukomm, Michael D Mueller
Mar 4, 2008·Gynecologic and Obstetric Investigation·Byung Chul JeeShin Yong Moon
Nov 30, 2013·Human Reproduction·G M BorrelliS Mechsner
Jan 24, 2014·Mediators of Inflammation·Dominic BertschiMichael D Mueller
Sep 1, 2014·Cellular and Molecular Bioengineering·Kathryn PollockPamela K Kreeger
Nov 9, 2010·Annual Review of Physiology·Albert Asante, Robert N Taylor
Dec 10, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Giovanni GrandiBrett McKinnon
Jul 15, 2015·Molecular Medicine Reports·Brett MckinnonNick A Bersinger
Mar 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kalliopi-Maria MargariIoannis Matalliotakis
Aug 18, 2009·Fertility and Sterility·Brett McKinnonMichael D Mueller
Aug 2, 2008·Fertility and Sterility·Sajal GuptaAshok Agarwal
Mar 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vida KocbekNick A Bersinger
Jul 1, 2008·Expert Opinion on Medical Diagnostics·Essam El-Din R OthmanAyman Al-Hendy
Nov 9, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Holger J Møller
Jan 21, 2014·American Journal of Obstetrics and Gynecology·Thibault ThubertCharles Chapron
Sep 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K NirgianakisM D Mueller
Dec 4, 2014·Trends in Endocrinology and Metabolism : TEM·Brett D McKinnonMichael D Mueller
Jul 15, 2016·Human Reproduction·K NirgianakisM Mueller
May 15, 2013·Reproductive Sciences·Ping WangXinmei Zhang
Jan 24, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi KobayashiHidekazu Oi
Nov 12, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Bonny SchollMichael D Mueller
Nov 17, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nick A BersingerMichael D Mueller
Oct 16, 2016·Oncotarget·Jessica E MillerChandrakant Tayade
Dec 17, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyJan Krejsek
Oct 18, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Anne J NielsenClaus V B Hviid
Sep 15, 2020·Hormone Molecular Biology and Clinical Investigation·Konstantinos NirgianakisMichael D Mueller
Jan 20, 2021·Analytica Chimica Acta·Thangapandi KalyaniSaikat Kumar Jana
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology
Apr 14, 2017·Journal of Gynecology Obstetrics and Human Reproduction·M CanisS Matsuzaki
May 19, 2021·Pain·Thomas AndrieuMichael D Mueller

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