Papuamine and haliclonadiamine, obtained from an Indonesian sponge Haliclona sp., inhibited cell proliferation of human cancer cell lines

Natural Product Research
Hiroyuki YamazakiMichio Namikoshi

Abstract

The extract of an Indonesian marine sponge Haliclona sp. showed potent cytotoxicity against human solid cancer cell lines, MCF-7 (breast), LNCap (prostate), Caco-2 (colon) and HCT-15 (colon) cells. Study on nuclear morphological changes and flow cytometric analysis suggested that the component(s) in the extract would induce an apoptosis to these cancer cells. Bioassay-guided isolation yielded two pentacyclic alkaloids, papuamine (1) and haliclonadiamine (2), which inhibited cell proliferation of six human cancer cell lines with IC50 values of 0.93-1.50 and 1.00-4.44 µM, respectively. Compounds 1 and 2 accumulated lymphoma U937 cells at sub-G1 phase and induced a condensation of chromatin and fragmentation of nucleus.

References

Mar 21, 2002·Natural Product Reports·D John Faulkner
Dec 15, 2010·Natural Product Reports·John W BluntMichèle R Prinsep

❮ Previous
Next ❯

Citations

Jan 30, 2014·Marine Drugs·Valentin A Stonik, Sergey N Fedorov
Nov 18, 2014·Marine Drugs·Ammad Ahmad FarooqiHsueh-Wei Chang
Aug 4, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Woori BaeJoohee Jung
Mar 13, 2019·Marine Drugs·Walter BalansaTill F Schäberle
Jul 12, 2014·Oncology Letters·Syu-Ichi KannoMasaaki Ishikawa
Jun 18, 2015·Journal of Natural Products·Delfly B AbdjulMichio Namikoshi

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.