PMID: 8949447Sep 1, 1996Paper

Papular mucinosis: is the inflammatory cell infiltrate neoplastic? The presence of a monotypic plasma cell population demonstrated by in situ hybridization

The British Journal of Dermatology
B J ClarkF D Lee

Abstract

Papular mucinosis is a condition reported to be associated with abnormal serum paraproteins and plasma cell dyscrasias. We report a patient with papular mucinosis, without a serum paraprotein or bone marrow plasmacytosis, in whom the affected skin contained a prominent perivascular plasma cell infiltrate. Using in situ hybridization, for kappa and lambda light chain mRNA, these plasma cells were demonstrably monotypic for lambda light chain and, therefore, presumably monoclonal and putatively neoplastic. We suggest that the absence of a serum paraprotein and marrow plasmacytosis does not exclude the existence of a plasma cell neoplasm in patients with papular mucinosis. Such plasma cell populations may exist in the affected skin, although their true nature and behaviour remains to be determined.

References

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Citations

Jul 9, 1999·International Journal of Dermatology·T AbaldeJ Toribio
Mar 11, 2008·Rheumatic Diseases Clinics of North America·Francesco Boin, Laura K Hummers
May 4, 2010·Dermato-endocrinology·Alison Layton
Jul 1, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·C MitteldorfM Tronnier
May 19, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Taku FujimuraSetsuya Aiba
Jan 3, 2019·The American Journal of Dermatopathology·Lacey B ElwynLaszlo Karai
Sep 13, 2014·Current Opinion in Rheumatology·Laura K Hummers

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