PapX, a P fimbrial operon-encoded inhibitor of motility in uropathogenic Escherichia coli.

Infection and Immunity
Amy N Simms, Harry L T Mobley

Abstract

Motility and adherence are two integral aspects of bacterial pathogenesis. Adherence, often mediated by fimbriae, permits bacteria to attach to host cells and establish infection, whereas flagellum-driven motility allows bacteria to disseminate to sites more advantageous for colonization. Both fimbriae and flagella have been proven important for virulence of uropathogenic Escherichia coli (UPEC). Reciprocal regulation is one mechanism by which bacteria may reconcile the contradictory actions of adherence and motility. PapX, a P fimbrial gene product of UPEC strain CFT073, is a functional homolog of MrpJ of Proteus mirabilis; ectopic expression of papX in P. mirabilis reduces motility. To define the connection between P fimbria expression and motility in UPEC, the role of papX in the regulation of motility of strain CFT073 was examined. Overexpression of papX decreased motility of CFT073, which correlated with both a significant reduction in flagellin protein synthesized and flagella assembled on the cell surface. Conversely, an increase in motility and flagellin production was seen in an isogenic papX deletion mutant of CFT073. Microarray and quantitative reverse transcription-PCR analysis indicated that repression of motility ...Continue Reading

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Citations

Nov 4, 2009·European Biophysics Journal : EBJ·Mickaël CastelainMagnus Andersson
Jun 12, 2013·Veterinary Microbiology·Qiangde DuanGuoqiang Zhu
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Nov 7, 2015·Microbiology Spectrum·Ferdinand X ChoongAgneta Richter-Dahlfors

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