PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans

Developmental Biology
Stephen E Von Stetina, Susan E Mango

Abstract

Cell polarity is a fundamental characteristic of epithelial cells. Classical cell biological studies have suggested that establishment and orientation of polarized epithelia depend on outside-in cues that derive from interactions with either neighboring cells or the substratum (Akhtar and Streuli, 2013; Chen and Zhang, 2013; Chung and Andrew, 2008; McNeill et al., 1990; Nejsum and Nelson, 2007; Nelson et al., 2013; Ojakian and Schwimmer, 1994; Wang et al., 1990; Yu et al., 2005). This paradigm has been challenged by examples of epithelia generated in the absence of molecules that mediate cell-cell or cell-matrix interactions, notably E-cadherin and integrins (Baas et al., 2004; Choi et al., 2013; Costa et al., 1998; Harris and Peifer, 2004; Raich et al., 1999; Roote and Zusman, 1995; Vestweber et al., 1985; Williams and Waterston, 1994; Wu et al., 2009). Here we explore an alternative hypothesis, that cadherins and integrins function redundantly to substitute for one another during epithelium formation (Martinez-Rico et al., 2010; Ojakian et al., 2001; Rudkouskaya et al., 2014; Weber et al., 2011). We use C. elegans, which possesses a single E-cadherin (Costa et al., 1998; Hardin et al., 2013; Tepass, 1999) and a single β-integ...Continue Reading

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Citations

May 26, 2017·Molecular Biology of the Cell·Stephen E Von StetinaSusan E Mango
Sep 15, 2017·The Journal of Cell Biology·Yuliya ZilbermanJeremy Nance
Aug 29, 2019·Annual Review of Cell and Developmental Biology·Melissa A PickettJessica L Feldman
Dec 15, 2020·Developmental Biology·Stéphanie GrimbertAlisa Piekny
Dec 18, 2020·Frontiers in Genetics·Saniya Deshmukh, Supreet Saini

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