Par3 is essential for the establishment of planar cell polarity of inner ear hair cells

Proceedings of the National Academy of Sciences of the United States of America
Andre Landin MaltXiaowei Lu

Abstract

In the inner ear sensory epithelia, stereociliary hair bundles atop sensory hair cells are mechanosensory apparatus with planar polarized structure and orientation. This is established during development by the concerted action of tissue-level, intercellular planar cell polarity (PCP) signaling and a hair cell-intrinsic, microtubule-mediated machinery. However, how various polarity signals are integrated during hair bundle morphogenesis is poorly understood. Here, we show that the conserved cell polarity protein Par3 is essential for planar polarization of hair cells. Par3 deletion in the inner ear disrupted cochlear outgrowth, hair bundle orientation, kinocilium positioning, and basal body planar polarity, accompanied by defects in the organization and cortical attachment of hair cell microtubules. Genetic mosaic analysis revealed that Par3 functions both cell-autonomously and cell-nonautonomously to regulate kinocilium positioning and hair bundle orientation. At the tissue level, intercellular PCP signaling regulates the asymmetric localization of Par3, which in turn maintains the asymmetric localization of the core PCP protein Vangl2. Mechanistically, Par3 interacts with and regulates the localization of Tiam1 and Trio, whic...Continue Reading

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Citations

Aug 18, 2020·The Journal of Cell Biology·Andre Landin MaltXiaowei Lu
Oct 16, 2019·Frontiers in Cell and Developmental Biology·Priyanka DuttaChristian Pohl
Nov 18, 2020·Biochemical Society Transactions·Joe MaltasAngeliki Malliri
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Andrew B Goryachev, Moisés Mallo
Feb 11, 2021·The FEBS Journal·Barry J Thompson
May 1, 2021·The Journal of Cell Biology·Shogo NakayamaSachiko Tsukita
May 4, 2021·Frontiers in Cell and Developmental Biology·Andre Landin MaltXiaowei Lu
May 19, 2021·Nature Communications·Katie S KindtBasile Tarchini
Mar 3, 2020·Developmental Biology·Nathalie S HoussinTimothy F Plageman

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