Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions

Peptides
Jean WillemsF Verdonck

Abstract

Parabutoporin (PP) affects motility and NADPH oxidase activity in normal human polymorphonuclear neutrophils and in granulocytic HL-60 cells. These PP-induced interactions utilize a Rac activation pathway. PP induces chemotaxis of neutrophils and HL-60 cells via a pertussis toxin-sensitive way, thus using trimeric G-proteins. The enhanced chemotaxis is also apparent in undifferentiated HL-60 cells which lack functional formyl peptide receptors. On the other hand, PP strongly reduces the superoxide production by the NADPH oxidase complex after either PMA or fMLP activation of granulocytes. These combined results strongly suggest a direct activation of G-proteins and subsequent Rac activation as the basis for the observed effects. The unexpected inhibitory effect of PP, despite Rac activation, on superoxide production in granulocytes is explained by the direct interaction of membrane localized PP which prevents the formation of a functional NADPH oxidase complex.

References

Jan 1, 1994·Annual Review of Cell Biology·A Hall
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ShiF Blecha
Oct 31, 2001·European Journal of Biochemistry·A GiangasperoA Tossi
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shijun LiMary C Dinauer
Nov 30, 2002·Toxicon : Official Journal of the International Society on Toxinology·Jean WillemsFons Verdonck
Oct 25, 2003·Biochemical and Biophysical Research Communications·Leentje MoermanSuzanne Bosteels

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Citations

Jul 23, 2005·IUBMB Life·Xian-Chun ZengRichard Hahin
Jul 12, 2013·Journal of Toxicology·Bennasr HmedZeghal Khaled Mounir
Oct 31, 2009·Toxicon : Official Journal of the International Society on Toxinology·Q RemijsenJ Willems
Oct 24, 2007·Toxicon : Official Journal of the International Society on Toxinology·L H du PlessisJ L du Plessis
Aug 12, 2009·Basic & Clinical Pharmacology & Toxicology·Hmed Ben NasrKhaled Mounir Zeghal
Aug 9, 2005·Peptides·Dale ElgarJohan du Plessis
Nov 5, 2013·Peptides·Ammar Almaaytah, Qosay Albalas
Aug 29, 2016·Toxicon : Official Journal of the International Society on Toxinology·Alessandra Daniele-SilvaMatheus F Fernandes-Pedrosa
Jan 1, 2019·International Journal of Peptide Research and Therapeutics·Arijit GhoshAshis Mukhopadhyay
Jul 13, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Jamel El-BennaPham My-Chan Dang

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