Paracellular absorption: a bat breaks the mammal paradigm

PloS One
Enrique Caviedes-VidalLye Otani

Abstract

Bats tend to have less intestinal tissue than comparably sized nonflying mammals. The corresponding reduction in intestinal volume and hence mass of digesta carried is advantageous because the costs of flight increase with load carried and because take-off and maneuverability are diminished at heavier masses. Water soluble compounds, such as glucose and amino acids, are absorbed in the small intestine mainly via two pathways, the transporter-mediated transcellular and the passive, paracellular pathways. Using the microchiropteran bat Artibeus literatus (mean mass 80.6+/-3.7 g), we tested the predictions that absorption of water-soluble compounds that are not actively transported would be extensive as a compensatory mechanism for relatively less intestinal tissue, and would decline with increasing molecular mass in accord with sieve-like paracellular absorption. Using a standard pharmacokinetic technique, we fed, or injected intraperitoneally the metabolically inert carbohydrates L-rhamnose (molecular mass = 164 Da) and cellobiose (molecular mass = 342 Da) which are absorbed only by paracellular transport, and 3-O-methyl-D-glucose (3OMD-glucose) which is absorbed via both mediated (active) and paracellular transport. As predicte...Continue Reading

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Citations

Aug 9, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Verónica FasuloEnrique Caviedes-Vidal
Nov 21, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edwin R PriceEnrique Caviedes-Vidal
May 23, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Juan Gabriel ChediackEnrique Caviedes-Vidal
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Aug 5, 2008·Molecular and Cellular Endocrinology·Rochelle Buffenstein, Mario Pinto
Jun 11, 2015·Integrative and Comparative Biology·Christopher R TracyKeith A Christian
Sep 25, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Verónica FasuloEnrique Caviedes-Vidal
Jul 14, 2019·Journal of Morphology·Antonio BrunEnrique Caviedes-Vidal
Nov 7, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Xingwen PengLibiao Zhang
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