Paracetamol - toxicity and microbial utilization. Pseudomonas moorei KB4 as a case study for exploring degradation pathway

Chemosphere
Joanna ŻurUrszula Guzik

Abstract

Paracetamol, a widely used analgesic and antipyretic drug, is currently one of the most emerging pollutants worldwide. Besides its wide prevalence in the literature only several bacterial strains able to degrade this compound have been described. In this study, we isolated six new bacterial strains able to remove paracetamol. The isolated strains were identified as the members of Pseudomonas, Bacillus, Acinetobacter and Sphingomonas genera and characterized phenotypically and biochemically using standard methods. From the isolated strains, Pseudomonas moorei KB4 was able to utilize 50 mg L-1 of paracetamol. As the main degradation products, p-aminophenol and hydroquinone were identified. Based on the measurements of specific activity of acyl amidohydrolase, deaminase and hydroquinone 1,2-dioxygenase and the results of liquid chromatography analyses, we proposed a mechanism of paracetamol degradation by KB4 strain under co-metabolic conditions with glucose. Additionally, toxicity bioassays and the influence of various environmental factors, including pH, temperature, heavy metals at no-observed-effective-concentrations, and the presence of aromatic compounds on the efficiency and mechanism of paracetamol degradation by KB4 strai...Continue Reading

References

Jan 1, 1987·Analytical Biochemistry·B Schwyn, J B Neilands
Mar 22, 2000·Chemical Research in Toxicology·J L BoltonT J Monks
Mar 29, 2003·The Journal of Pharmacology and Experimental Therapeutics·Qi CaiMaurice B Burg
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xinhe WangJiyan Ma
Nov 15, 2008·Current Opinion in Structural Biology·John D Lipscomb
Feb 26, 2011·Biotechnology Research International·Nilanjana Das, Preethy Chandran
Apr 9, 2011·World Journal of Microbiology & Biotechnology·Danuta WojcieszyńskaKatarzyna Hupert-Kocurek
Jan 3, 2012·Research in Microbiology·Kostlend MaraRenato Fani
Apr 6, 2012·PloS One·Mei-Hui LinYi-Ching Cheng
May 31, 2012·Applied Microbiology and Biotechnology·Lili ZhangJianmeng Chen
Oct 12, 2012·Applied Microbiology and Biotechnology·Shijin WuJianmeng Chen
Nov 6, 2012·Journal of Hazardous Materials·Edgar MoctezumaCarlos Montalvo
Mar 1, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Jun HuYu Liu
Apr 19, 2013·Journal of Applied Microbiology·J M KrondaS E Maddocks
Jun 15, 2013·Environmental Science and Pollution Research International·S C AntunesBruno Nunes
Dec 10, 2013·Water Research·Juying LiJay Gan
Mar 29, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Keiko MurakamiMasataka Yoshino
Dec 3, 2014·Chemosphere·M Herrero, D C Stuckey
Jun 10, 2015·The Journal of Biological Chemistry·Eun-Ik Koh, Jeffrey P Henderson
Oct 20, 2015·Water, Air, and Soil Pollution·Ariel MarchlewiczDanuta Wojcieszyńska
Mar 24, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sandra MatthijsHerbert Budzikiewicz
Apr 22, 2016·Bulletin of Environmental Contamination and Toxicology·Juan DuMei-Ying Xu
Nov 5, 2016·Ecotoxicology and Environmental Safety·Muhammad AshfaqChang-Ping Yu
Nov 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Megan Y Andrews, Owen Duckworth

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Citations

Sep 1, 2019·Water Environment Research : a Research Publication of the Water Environment Federation·Bo LiuChein-Chi Chang
Jun 21, 2018·Environmental Science and Pollution Research International·Joanna ŻurUrszula Guzik
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert SurmaUrszula Guzik
Nov 21, 2020·Environmental Science and Pollution Research International·Ikram RouibahHedi Ben Mansour
Jan 4, 2022·Folia Microbiologica·Rosane Dos S GrignetCaroline da C S Gonçalves

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