PMID: 2904987Jul 1, 1988Paper

Paracetamol confers resistance to ethanol-induced gastric mucosal damage in rats

The Journal of Pharmacy and Pharmacology
Y K PoonC W Ogle


Paracetamol given orally or subcutaneously did not produce any observable gastric mucosal damage, nor did it change the acidity of the residual secretion in rat stomachs. However, it delayed the gastric emptying rate and increased the residual volume of gastric secretion. Pretreatment with paracetamol 250 mg kg-1 significantly prevented ethanol-induced gastric ulceration. Although it did not influence ethanol-stimulated acid secretion, it increased the mucosal mucus content in the ethanol-treated animals. The findings suggest that the protective mechanism of paracetamol against ethanol-induced damage is likely to be due to improved gastric mucosal integrity, through an increase in the adherent mucosal mucus which protects the underlying delicate cellular structures.


Oct 15, 1979·European Journal of Pharmacology·A Danon, G Assouline
Oct 15, 1979·European Journal of Pharmacology·W J McDonald-Gibson, H O Collier
Jul 1, 1986·The Journal of Pharmacy and Pharmacology·S H WongC H Cho
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·M W KooC H Cho
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·M W KooC W Ogle
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·C J HawkeyK W Somerville
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J L Wallace, B J Whittle
Dec 1, 1986·Archives of Internal Medicine·W R BartleJ Lazor
Sep 15, 1985·Experientia·C W OgleS H Wong
Jan 1, 1981·The Journal of Pharmacy and Pharmacology·J L LeelingR J Helms
Jul 1, 1981·The Journal of Pharmacy and Pharmacology·A A Van KolfschotenM Basista
Dec 1, 1983·Prostaglandins, Leukotrienes, and Medicine·E L TolmanM E Rosenthale
Feb 1, 1983·Drug and Alcohol Dependence·H Kalant
Jun 15, 1983·Toxicology and Applied Pharmacology·A A Van KolfschotenJ Van Noordwijk


Aug 16, 1991·European Journal of Pharmacology·M TrautmannB A Peskar
Jul 1, 1990·The Journal of Pharmacy and Pharmacology·C H Cho, C W Ogle
Aug 1, 1989·The Journal of Pharmacy and Pharmacology·Y K PoonC W Ogle

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