PMID: 9183313May 1, 1997Paper

Paracetamol-induced cholestatic and granulomatous liver injuries

Journal of Internal Medicine
A LindgrenR Olsson

Abstract

To describe uncommon (previously unreported) types of adverse liver reactions to paracetamol. In addition to describing patients, with uncommon types of liver reactions to paracetamol, admitted to our hospitals, we surveyed all the liver reactions to paracetamol reported to the Swedish Adverse Drug Reactions Advisory Committee from 1973 to 1993. The Swedish population of 8 million inhabitants. Extensive medical evaluation. We found one case with a cholestatic liver reaction and one with granulomatous hepatitis. The reactions were probably idiosyncratic and took several months to disappear. In addition to the well-known dose-related toxic liver damage paracetamol may rarely cause non-dose-related severe, prolonged cholestasis or granulomatous hepatitis with cirrhosis.

Citations

May 19, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D B CoullI G Finlay
Dec 7, 2007·La Revue de médecine interne·D Vital DurandH Rousset
Mar 16, 2007·Seminars in Diagnostic Pathology·David E Kleiner
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Gian Luca GraziAntonio Daniele Pinna
Aug 29, 2007·Pharmacotherapy·Richard C Dart, Elise Bailey
Apr 6, 2004·Clinics in Liver Disease·Tonantzin Matheus, Santiago Muñoz
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rolf OlssonMatty Persson
Jul 19, 2008·World Journal of Gastroenterology : WJG·Yukihiro Shimizu

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