Paracetamol induced skin blood flow and blood pressure changes in febrile intensive care patients: An observational study

Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses
Martin BoyleDavid Bihari

Abstract

To determine the relationship between paracetamol administration and skin blood flow (skBF) and blood pressure (BP) in critically ill patients treated for fever. Prospective, observational study. Intensive care units of university teaching hospital. 29 adults (17 males and 12 females), aged 58±15 years treated with enteral or intravenous paracetamol for fever. APACHE II score was 17.2±8.3 and admission classifications were 41% medical (n=12), 31% surgical (n=9), and 28% neurological intervention (n=8). Thirty healthy afebrile volunteers were also studied after ingesting 1g paracetamol. Temperature, BP and skBF (laser Doppler flowmetry perfusion units) were recorded 15 min prior to administration of paracetamol, at administration (T0) and then for every 15 min for 60 min. Cutaneous vascular conductance (CVC=skBF/mean arterial pressure) was calculated. Thirty data sets were recorded from 29 patients. Temperature at T0 was 38.7±0.6°C. BP decreased over the study period whilst skBF and CVC increased (repeated measured ANOVA, p<.05). Systolic BP decreased significantly (p<.01) at all post-administration times and was 90±13% of T0 at 60 min. CVC was 128±48% of T0 at 60 min. Systolic BP fell by a clinically significant amount (≥15%) i...Continue Reading

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Citations

Jan 1, 2014·European Journal of Pediatrics·Pierluigi MarzuilloEgidio Barbi
Mar 20, 2012·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Adéla KrajčováFrantišek Duška
May 14, 2011·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Patrick Ziemann-Gimmel
Sep 10, 2016·Anaesthesia·F Hanks, C McKenzie
Nov 1, 2016·Postgraduate Medical Journal·Eric EhieliSrinivas Pyati
May 3, 2019·The Annals of Pharmacotherapy·Erin N MaxwellJason A Ferreira
Jan 25, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Barbara-Jo AchuffCraig G Rusin
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jennifer van der HorstThomas A Jepps
Mar 31, 2021·The American Journal of the Medical Sciences·Stephen A Hoption Cann
Jun 30, 2021·Journal of Clinical Neurology·Sang Yeon KimHyun Goo Kang

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