Paracetamol poisoning in adolescents in an Australian setting: not quite adults

Emergency Medicine Australasia : EMA
Andis Graudins

Abstract

To describe and compare the characteristics of paracetamol poisoning in adolescent and adult patients. Descriptive retrospective case series of adolescent (12-17 years) and adult (>18 years) patients presenting to a metropolitan hospital network ED, diagnosed with paracetamol poisoning from October 2009 to September 2013. There were 220 adolescent (median age 16 years, 47% treated with acetylcysteine [NAC]) and 647 adult presentations (median age 27 years, 42% treated with NAC) for paracetamol poisoning in the study period. Adolescent patients were more frequently women (89% vs 76%; odds ratio [OR] 2.4; 95% confidence interval [CI] 1.5-3.8) and ingested similar amounts of paracetamol (18 g) when requiring NAC treatment. Adolescents were more likely to ingest paracetamol as a single agent (53% vs 34%; OR 2.2; 95% CI 1.6-3.0) and less likely to ingest compound paracetamol products than adults (18% vs 29%; OR 0.54; 95% CI 0.36-0.79). Adolescents were less likely to report accidental supratherapeutic ingestion of paracetamol (0.02% vs 10%; OR 0.23; 95% CI 0.09-0.58), or co-ingestion of prescription medications (25% vs 43%; OR 0.4; 95% CI 0.31-0.62). Adolescents had more frequent histamine release reactions to NAC than adults (17% v...Continue Reading

References

Feb 23, 1981·Archives of Internal Medicine·B H RumackI A Amara
Sep 1, 1996·Archives of Disease in Childhood·R J GilbertsonW Myers
Jun 28, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·W Stephen WaringJanice M Pettie
Sep 23, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Nasrin PakravanD Nicholas Bateman
Mar 13, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·E A Sandilands, D N Bateman

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Citations

Nov 26, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anselm Wong, Andis Graudins
Oct 4, 2016·Emergency Medicine Australasia : EMA·Mandira HiremathAndis Graudins
Jun 24, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Angela L ChiewNicholas A Buckley
Jun 19, 2017·European Journal of Clinical Pharmacology·Anselm WongAndis Graudins
Jul 28, 2020·Pharmacoepidemiology and Drug Safety·Alexandra G HopkinsGary A Smith
Jul 15, 2015·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Peter A Chyka
Apr 24, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Julia ShekunovMagdalena Romanowicz

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