Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate.

Metabolic Brain Disease
Jacques ViljoenGisella Terre'Blanche

Abstract

Valproate administration increases the level of the inhibitory transmitter, glycine, in the urine and plasma of patients and experimental animals. Nonketotic hyperglycinemia (NKH), an autosomal recessive disorder of glycine metabolism, causes increased glycine concentrations in blood, urine, and cerebrospinal fluid (CSF), most likely due to a defect in the glycine cleavage enzyme or possibly deficits in glycine transport across cell membranes. We investigated the relationship between the hyperglycinemic effect of valproate and induced pyroglutamic aciduria via paracetamol in the vervet monkey. Firstly it was determined if valproate could induce hyperglycinemia in the monkey. The second aim was to increase glutamic acid (oxoproline) urine excretion using paracetamol as a pre-treatment and to assess whether valproate has an influence on the γ-glutamyl cycle. Hyperglycinemia was induced in healthy vervet monkeys when treated with a single oral dose of 50 mg/kg valproate. An acute dose of 50 mg/kg paracetamol increased oxoproline in the urine. Pre-treatment with paracetamol opposed the hyperglycinemic effect of valproate. However, the CSF:serum glycine ratio in a nonketotic monkey increased markedly after paracetamol treatment and ...Continue Reading

References

Jan 11, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·P E KeckC B Nemeroff
Jan 1, 1990·Journal of Inherited Metabolic Disease·J J PittJ Christodoulou
Oct 1, 1988·Acta Neurologica Scandinavica·K V Sørensen
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·M Orlowski, A Meister
Oct 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·S JoosteK M Gibson
Oct 11, 2001·Molecular Genetics and Metabolism·D A Applegarth, J R Toone
Feb 28, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Petr HusekDavid Slabík
Apr 30, 2005·Journal of Medical Primatology·Choong-Yong KimSang-Seop Han
Dec 21, 2005·The Journal of Nutrition·Richard A HawkinsJuan R Viña
Nov 1, 2006·Pediatric Neurology·Peter F MorrisonW Donald Shields
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Andrew Z FenvesMichael Emmett
Oct 23, 2008·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Goro KikuchiKoichi Hiraga
Apr 2, 2011·Journal of Child Neurology·Radhika DhamijaElaine C Wirrell

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Citations

Jun 24, 2019·Metabolic Brain Disease·Zandisiwe E MagwebuChesa G Chauke
Nov 6, 2014·The Journal of Biological Chemistry·Shotaro SasakiKen Iseki

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